miRNA-223 is a potential diagnostic and prognostic marker for osteosarcoma
| Autor: | Junbo Dong, Ran Liu, Yilin Liu, Wensheng Liao, Limin Wang, Pei Shi |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
musculoskeletal diseases lcsh:Diseases of the musculoskeletal system lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine mir-223 microRNA Diagnosis medicine neoplasms Osteosarcoma Cell growth business.industry Cell migration lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Prognosis miR-223 In vitro 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer cell Cancer research lcsh:RC925-935 business Research Paper |
| Zdroj: | Journal of Bone Oncology, Vol 5, Iss 2, Pp 74-79 (2016) Journal of Bone Oncology |
| ISSN: | 2212-1374 |
| DOI: | 10.1016/j.jbo.2016.05.001 |
| Popis: | Background: MicroRNA-223 (miR-223) has been shown to be a potential diagnostic and prognostic marker for several cancers. In addition, miR-223 has been reported to suppress osteosarcoma cell proliferation in vitro. However, the clinical value of miR-223 is still unknown. Methods: We detected the expression of miR-223 expression in the serum of osteosarcoma patients and in osteosarcoma cancer cells using RT-PCR. We compared the serum expression of miR-223 with the clinicopathological characteristics and survival of osteosarcoma patients. Finally, we explored the role of miR-223 on the invasion of osteosarcoma cancer cells using cell migration and invasion assays. Results: We observed that the expression of miR-223 was significantly decreased in the serum of osteosarcoma patients and osteosarcoma cancer cells compared to healthy controls (P |
| Databáze: | OpenAIRE |
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