Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort
| Autor: | Petra H.M. Peeters, Marc J. Gunter, Rudolf Kaaks, Kim Overvad, Fränzel J.B. Van Duijnhoven, Francesca L. Crowe, Aurelio Barricarte, Anne Tjønneland, Antoine Racine, Stefan Söderberg, Richard Palmqvist, Françoise Clavel-Chapelon, Isabelle Romieu, Krasimira Aleksandrova, Heiner Boeing, Jytte Halkjær, Virginia Menéndez, Tobias Pischon, José María Huerta, María José Sánchez, Annekatrin Lukanova, H. Bas Bueno-de-Mesquita, Dimitrios Trichopoulos, Naomi E. Allen, Mazda Jenab, Nickolas Wareham, Valeria Pala, Veronika Fedirko, Sabina Rinaldi, Marie-Christine Boutron-Ruault, Antonia Trichopoulou, Domenico Palli, Amalia Mattiello, Eugene Jansen, Elio Riboli, Pilar Amiano, Kay-Tee Khaw, Genevieve Buckland, Pagona Lagiou, Rosario Tumino, Sabine Westphal, Paolo Vineis |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Leptin Male Cancer Research medicine.medical_specialty Colorectal cancer Nutritional Status Peptide hormone Cohort Studies Insulin resistance Internal medicine medicine Humans Prospective Studies Aged Leptin receptor Adiponectin business.industry digestive oral and skin physiology Middle Aged medicine.disease Obesity European Prospective Investigation into Cancer and Nutrition Europe Endocrinology Oncology Receptors Leptin Female business Colorectal Neoplasms hormones hormone substitutes and hormone antagonists |
| Zdroj: | Aleksandrova, K, Boeing, H, Jenab, M, Bueno-de-Mesquita, H B, Jansen, E, van Duijnhoven, F J B, Rinaldi, S, Fedirko, V, Romieu, I, Riboli, E, Gunter, M J, Westphal, S, Overvad, K, Tjønneland, A, Halkjær, J, Racine, A, Boutron-Ruault, M-C, Clavel-Chapelon, F, Kaaks, R, Lukanova, A, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Mattiello, A, Pala, V, Palli, D, Tumino, R, Vineis, P, Buckland, G, Sánchez, M-J, Amiano, P, Huerta, J M, Barricarte, A, Menéndez, V, Peeters, P H, Söderberg, S, Palmqvist, R, Allen, N E, Crowe, F L, Khaw, K-T, Wareham, N & Pischon, T 2012, ' Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort ', Cancer Research, vol. 72, no. 20, pp. 5328-5337 . https://doi.org/10.1158/0008-5472.CAN-12-0465 |
| Popis: | Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40–0.76; Ptrend = 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28–0.63, Ptrend = 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48–1.44, Ptrend = 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56–1.29, Ptrend = 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. Cancer Res; 72(20); 5328–37. ©2012 AACR. |
| Databáze: | OpenAIRE |
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