Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry
| Autor: | Shaunik Sharma, Sreekanth Puttachary, Edward Beamer, Thimmasettappa Thippeswamy, Abby Sexton, Joseph Crutison, Karen Tse |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Time Factors Video Recording lcsh:Medicine Kainate receptor Status epilepticus Electroencephalography Severity of Illness Index Epileptogenesis Epilepsy Status Epilepticus Animals Telemetry Medicine lcsh:Science Survival rate Monitoring Physiologic Diazepam Kainic Acid Multidisciplinary Dose-Response Relationship Drug medicine.diagnostic_test business.industry lcsh:R medicine.disease Cortex (botany) Mice Inbred C57BL Disease Models Animal Anesthesia Anticonvulsants lcsh:Q medicine.symptom business Injections Intraperitoneal Research Article medicine.drug |
| Zdroj: | PLoS ONE, Vol 10, Iss 7, p e0131705 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The C57BL/6J mouse as a model of seizure/epilepsy is challenging due to high mortality and huge variability in response to kainate. We have recently demonstrated that repeated administration of a low dose of kainate by intraperitoneal route can induce severe status epilepticus (SE) with 94% survival rate. In the present study, based on continuous video-EEG recording for 4-18 weeks from epidurally implanted electrodes on the cortex, we demonstrate that this method also induces immediate epileptogenesis ( |
| Databáze: | OpenAIRE |
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