Microbiological Findings in Febrile Neutropenia
| Autor: | Luis Casanova-Cardiel, José González-Llaven, Eduardo Mateos-García, E Sanchez-Cortés, Jesús Gaytán-Martínez, José Luis Fuentes-Allen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutropenia Adolescent Fever Bacteremia Microbial Sensitivity Tests Gram-Positive Bacteria Internal medicine Gram-Negative Bacteria medicine Humans Prospective Studies Fungemia Aged Bone Marrow Transplantation biology business.industry General Medicine Middle Aged biology.organism_classification medicine.disease Anti-Bacterial Agents Leukemia Lymphoid Transplantation Leukemia Leukemia Myeloid Acute Disease Immunology Female Penicillium marneffei business Meningitis Febrile neutropenia |
| Zdroj: | Archives of Medical Research. 31:388-392 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/s0188-4409(00)00080-1 |
| Popis: | Background This study was carried out to assess the isolation rate of bacterial and fungal causative agents in Mexican neutropenic adults with hematological neoplasia. Methods A prospective observational survey involving 120 consecutive episodes of febrile neutropenia during 1 year was carried out. These episodes were observed in 630 patients discharged with diagnoses of leukemia or lymphoma, or after bone-marrow transplantation. Results At least one pathogen was isolated in 42 of 120 episodes (35%), and was present in 39 patients with acute myeloid leukemia (AML) (43%), acute lymphoblastic leukemia (ALL) (23%), and in patients who underwent bone-marrow transplantation (20%). Primary bacteremia was the most frequent cause of fever (24 episodes, 57%), followed by intravascular device–related infections (5 episodes, 17%), and soft-tissue infections (5 episodes, 15%). Escherichia coli (33%) was the most frequently isolated agent of primary bacteremia, followed by coagulase-negative Staphylococcus (29%), and Klebsiella oxytoca (16%). Fungal infection was responsible for five events (4%): two episodes of pneumonia ( Penicillium marneffei and Aspergillus fumigatus , one event each); two cases of fungemia, one due to Candida tropicalis and one to Rhodotorula gluttinis , and one cryptococcal meningitis event. Conclusions The isolation rate, approximately 30%, was in accordance with previous reports; similar percentages of Gram-positive and Gram-negative isolates were found. A remarkably low rate of viridans group streptococci and fungal agents was observed, despite the fact that neutropenia is the main risk factor for infection due to these agents. Studies reporting local microbiological findings are necessary because they support an antibiotic choice for prophylaxis or therapy more accurately than reports from other areas. |
| Databáze: | OpenAIRE |
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