Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study
| Autor: | Marta Di Nicola, Leonardo Mastropasqua, Silvio Di Staso, Lisa Toto, Rossella D'Aloisio, Marco Ciancaglini, Luca Di Antonio, Alessandra Mastropasqua, Giuseppe Di Martino, Alfonso Senatore, Daniele Tognetto |
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| Přispěvatelé: | Mastropasqua, L., Di Staso, S., D'Aloisio, R., Mastropasqua, A., Di Antonio, L., Senatore, A., Ciancaglini, M., Di Nicola, M., Di Martino, G., Tognetto, D., Toto, L. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures optical coherence tomography angiography 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Clinical Research Diabetic macular edema Ophthalmology medicine Dexamethasone intravitreal ranibizumab injections Plexus business.industry Intravitreal ranibizumab injection Retrospective cohort study Intravitreal dexamethasone implant Intravitreal ranibizumab injections Optical coherence tomography angiography eye diseases intravitreal dexamethasone implant lcsh:RE1-994 030221 ophthalmology & optometry Tonicity Implant Ranibizumab medicine.symptom business diabetic macular edema Microperimetry medicine.drug |
| Zdroj: | International Journal of Ophthalmology, Vol 12, Iss 10, Pp 1589-1597 (2019) |
| ISSN: | 2227-4898 2222-3959 |
| Popis: | AIM: To investigate the efficacy and safety of ranibizumab (RZB group) and dexamethasone implant (DEX group) intravitreal treatments in patients with treatment-naïve center involved diabetic macular edema (DME) by means of functional and morphological assessments. METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity (BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness (CMT) by means of structural optical coherence tomography (OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases. RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups with a greater increase in the DEX group compared to the RBZ group (P=0.030). Microperimetry significantly differed during follow-up between the two treatments (P=0.031). In both groups CMT significantly decreased (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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