Positron Emission Tomographic Measurement of Acute Hemodynamic Changes in Primate Middle Cerebral Artery Occlusion
| Autor: | Hiroshi TENJIN, Satoshi UEDA, Norihiko MIZUKAWA, Yoshio IMAHORI, Akihiko HINO, Yoshio OHMORI, Kiyoshi YASUKOCHI, Hisamitsu NAKAHASHI, Kazuo WAKITA, Hitoshi HORII, Ryou FUJII |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Cerebral arteries Ischemia Hemodynamics Constriction Internal medicine Occlusion medicine Animals Middle cerebral artery occlusion medicine.diagnostic_test business.industry Cerebral Arteries medicine.disease Cerebral blood flow Ischemic Attack Transient Positron emission tomography Cerebrovascular Circulation Cardiology Macaca Female Surgery Neurology (clinical) Radiology business Tomography Emission-Computed |
| Zdroj: | Neurologia medico-chirurgica. 32:805-810 |
| ISSN: | 1349-8029 0470-8105 |
| DOI: | 10.2176/nmc.32.805 |
| Popis: | Specific hemodynamic changes in acute ischemia were investigated using a middle cerebral artery occlusion primate model and positron emission tomography. The cerebral blood flow (CBF), cerebral blood volume, oxygen extraction fraction (OEF), and cerebral metabolic rate for oxygen were measured 1, 3, and 9 hours after occlusion. OEF showed an increase in ischemic areas, and especially where CBF was below 18 ml/100 gm/min 1 hour after occlusion the OEF increased significantly (0.69 +/- 0.20, p < 0.05). Nine hours after occlusion, the OEF values were lower compared to those 1 and 3 hours after occlusion. Areas where CBF ranged from 18 to 31 ml/100 gm/min showed an increase in OEF at all times (p < 0.05). Clearly, OEF changes remarkably in the acute stage. |
| Databáze: | OpenAIRE |
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