Salvage treatment for local or local-regional recurrence after initial breast conservation treatment with radiation for ductal carcinoma in situ
| Autor: | Marie E. Taylor, Alain Fourquet, Ivo A. Olivotto, Anuja Jhingran, Frank A. Vicini, Eric A. Strom, Bruce G. Haffty, Harry Bartelink, Wei-Ting Hwang, Elaine Wai, Lori J. Pierce, Nina Bijker, Lawrence J. Solin, François Campana, Marsha D. McNeese, Lawrence B. Marks |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Axillary lymph nodes medicine.medical_treatment Breast Neoplasms Breast Conservation Treatment Mastectomy Segmental Cohort Studies medicine Carcinoma Humans Salvage Therapy business.industry Carcinoma in situ Ductal carcinoma Middle Aged medicine.disease Prognosis Surgery Radiation therapy medicine.anatomical_structure Carcinoma Intraductal Noninfiltrating Oncology Female Neoplasm Recurrence Local Breast carcinoma business Mastectomy Mammography |
| Zdroj: | European journal of cancer (Oxford, England, 41(12), 1715-1723. Elsevier Limited |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2005.03.028 |
| Popis: | The present study evaluated the outcome of salvage treatment for women with local or local-regional recurrence after initial breast conservation treatment with radiation for mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast. The study cohort consisted of 90 women with local only first failure (n=85) or local-regional only first failure (n=5). The histology at the time of recurrence was invasive carcinoma for 53 patients (59%), non-invasive carcinoma for 34 patients (38%), angiosarcoma for one patient (1%), and unknown for two patients (2%). The median follow-up after salvage treatment was 5.5 years (mean=5.8 years; range=0.2-14.2 years). The 10-year rates of overall survival, cause-specific survival, and freedom from distant metastases after salvage treatment were 83%, 95%, and 91%, respectively. Adverse prognostic factors for the development of subsequent distant metastases after salvage treatment were invasive histology of the local recurrence and pathologically positive axillary lymph nodes. These results demonstrate that local and local-regional recurrences can be salvaged with high rates of survival and freedom from distant metastases. Close follow-up after initial breast conservation treatment with radiation is warranted for the early detection of potentially salvageable local and local-regional recurrences. |
| Databáze: | OpenAIRE |
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