Cellular and humoral immune response to SARS-CoV-2 vaccination and booster dose in immunosuppressed patients: An observational cohort study
| Autor: | Lu M. Yang, Cristina Costales, Muthukumar Ramanathan, Philip L. Bulterys, Kanagavel Murugesan, Joseph Schroers-Martin, Ash A. Alizadeh, Scott D. Boyd, Janice M. Brown, Kari C. Nadeau, Sruti S. Nadimpalli, Aileen X. Wang, Stephan Busque, Benjamin A. Pinsky, Niaz Banaei |
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| Rok vydání: | 2022 |
| Předmět: |
Male
COVID-19 Vaccines Clinical Sciences Antibodies Viral Microbiology Antibodies Vaccine Related Biodefense Virology Humans Viral BNT162 Vaccine Retrospective Studies IGRA Ad26COVS1 SARS-CoV-2 Prevention Vaccination Immunity Humoral COVID-19 Viral Vaccines Middle Aged Immunity Humoral Serology Emerging Infectious Diseases Infectious Diseases Good Health and Well Being Medical Microbiology Immunoglobulin G Female Immunization Infection Immunosuppression |
| Popis: | BackgroundHumoral and cellular immune responses to SARS-CoV-2 vaccination among immunosuppressed patients remain poorly defined, as well as variables associated with poor response.MethodsWe performed a retrospective observational cohort study at a large Northern California healthcare system of infection-naïve individuals fully vaccinated against SARS-CoV-2 (mRNA-1273, BNT162b2, or Ad26.COV2.S) with clinical SARS-CoV-2 interferon gamma release assay (IGRA) ordered between January through November 2021. Humoral and cellular immune responses were measured by anti-SARS-CoV-2 S1 IgG ELISA (anti-S1 IgG) and IGRA, respectively, following primary and/or booster vaccination.Results496 immunosuppressed patients (54% female; median age 50 years) were included. 62% (261/419) of patients had positive anti-S1 IgG and 71% (277/389) had positive IGRA after primary vaccination, with 20% of patients having a positive IGRA only. Following booster, 69% (81/118) had positive anti-S1 IgG and 73% (91/124) had positive IGRA. Factors associated with low humoral response rates after primary vaccination included anti-CD20 monoclonal antibodies (P |
| Databáze: | OpenAIRE |
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