Central Nervous System Metastasis in Neuroblastoma: From Three Decades Clinical Experience to New Considerations in the Immunotherapy Era

Autor: Angela Mastronuzzi, Giovanna Stefania Colafati, Andrea Carai, Maria D’Egidio, Francesco Fabozzi, Francesca Del Bufalo, Maria Felicia Villani, Giada Del Baldo, Sabina Vennarini, Costanza Canino, Angela Di Giannatale, Paolo Tomà, Maria Carmen Garganese, Maria Antonietta De Ioris
Rok vydání: 2022
Předmět:
Zdroj: Cancers; Volume 14; Issue 24; Pages: 6249
ISSN: 2072-6694
Popis: Central nervous system (CNS) metastatic spread in neuroblastoma (NB) is rare and occurs more often at relapse/progression. We report on CNS involvement in high risk (HR) NB over 25 years. For this retrospective study, we reviewed the CNS imaging of all the patients treated at Bambino Gesù Children Hospital from 1 July 1996 to 30 June 2022. A total of 128 patients with HR NB were diagnosed over 26 years. Out of 128 patients, CNS metastatic spread occurred in 6 patients: 3 patients presented a metastatic spread at diagnosis, while in 3 patients, CNS was involved at relapse. Overall, the rate of occurrence of CNS spread is 4.7% with the same distribution at diagnosis and at relapse, namely 2.3%. Interestingly, CNS spread at diagnosis was observed only before 2012, whereas CNS was observed at relapse only after 2012, in the immunotherapy era. CNS metastases presented similar imaging features at diagnosis and at relapse, with a peculiar hemorrhagic aspect and mainly hemispheric localization in patients with bone skull involvement at the time of diagnosis. The outcome is dismal, and 3 out of 6 patients died for progressive disease.
Databáze: OpenAIRE
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