The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults
| Autor: | Mercé Albert-Bayo, Ana M González-Castro, Javier Santos, Beatriz Lobo, Carmen Alonso-Cotoner, Elba Expósito, John-P Ganda Mall, Mar Abril-Gil |
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| Přispěvatelé: | Institut Català de la Salut, [Abril-Gil M, Albert-Bayo M, Expósito E, González-Castro AM, Lobo B] Grup de Neuro-Immuno-Gastroenterologia, Unitat de Fisiologia i Fisiopatologia Digestiva, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Alonso-Cotoner C, Santos J] Grup de Neuro-Immuno-Gastroenterologia, Unitat de Fisiologia i Fisiopatologia Digestiva, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ganda Mall JP] Grup de Neuro-Immuno-Gastroenterologia, Unitat de Fisiologia i Fisiopatologia Digestiva, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Diarrhea Xyloglugan 030213 general clinical medicine medicine.medical_specialty Pathological Conditions Signs and Symptoms::Signs and Symptoms::Signs and Symptoms Digestive::Diarrhea [DISEASES] afecciones patológicas signos y síntomas::signos y síntomas::signos y síntomas digestivos::diarrea [ENFERMEDADES] Respiratory Medicine and Allergy Review Bismuth subsalicylate Permeability Irritable Bowel Syndrome 03 medical and health sciences Therapeutic approach 0302 clinical medicine Mucosa intestinal Chronic diarrhea Internal medicine medicine Humans Adults Pharmacology (medical) Intestinal Mucosa Intensive care medicine Irritable bowel syndrome Diarrea - Tractament Digestive System::Gastrointestinal Tract::Intestines::Intestinal Mucosa [ANATOMY] Lungmedicin och allergi Gelatine tannate Intestinal permeability business.industry enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritable [ENFERMEDADES] Smectite intestinal permeability Functional diarrhea General Medicine Mucoprotectans Mucus medicine.disease Rheumatology Còlon irritable - Tractament 030220 oncology & carcinogenesis Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases Functional::Irritable Bowel Syndrome [DISEASES] sistema digestivo::tracto gastrointestinal::intestinos::mucosa intestinal [ANATOMÍA] business Dysbiosis medicine.drug |
| Zdroj: | Scientia Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Advances in Therapy |
| Popis: | Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing a variety of chronic diarrheal diseases. In addition to current pharmacological therapies, there is growing interest in alternative products such as mucoprotectants, which form a mucoadhesive film over the epithelium to reduce and protect against the development of altered intestinal permeability, dysbiosis, and mucosal micro-inflammation. This manuscript focuses on chronic diarrhea in adults, and we will review recent evidence on the ability of these natural compounds to improve symptoms associated with chronic diarrhea and to exert protective effects for the intestinal barrier. Funding Agencies|Fondo Europeo de Desarrollo Regional (FEDER), Fondo de Investigacion Sanitaria and Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Subdireccion General de Investigacion Sanitaria, M [FIS LOBO 2019, FI20/00256, PI17/0190, PI15/00301]; Ajuts per a la contractacio de personal investigador FI-Agencia de Gestio dAjuts Universitaris i de Recerca (AGAUR) [FIS LOBO 2019, FI20/00256, PI17/0190, PI15/00301]; Generalitat de CatalunyaGeneralitat de Catalunya [FIS LOBO 2019, FI20/00256, PI17/0190, PI15/00301]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [FIS LOBO 2019, FI20/00256, PI17/0190, PI15/00301]; European Commision [FIS LOBO 2019, FI20/00256, PI17/0190, PI15/00301]; CIBERehd [CB06/04/0021]; [2019-00653]; [2020FI_B1 00127]; [2019FI_B 00817]; [848228] |
| Databáze: | OpenAIRE |
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