Angiotensin II-norepinephrine relationship in the central nervous system
| Autor: | N. A. Vidal, A. E. Domínguez, B. E. Fernández, A. Martinez Seeber |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Cytoplasm medicine.medical_specialty Physiology medicine.medical_treatment Central nervous system Hypothalamus Blood Pressure Endogeny Nephrectomy Biochemistry Plasma renin activity Norepinephrine Internal medicine Renin medicine Animals Medulla Oblongata Chemistry Angiotensin II Brain Rats Inbred Strains Rats medicine.anatomical_structure Endocrinology nervous system Medulla oblongata medicine.drug |
| Zdroj: | Archives Internationales de Physiologie et de Biochimie. 90:269-275 |
| ISSN: | 0003-9799 |
| DOI: | 10.3109/13813458209103824 |
| Popis: | The effects of angiotensin II (AII) and bilateral nephrectomy on [3H] norepinephrine (NE) uptake in hypothalamus and medulla oblongata were studied in male rats. The endogenous NE content in hypothalamus increased 4, 24 and 48 h after nephrectomy with a simultaneous decreasing of plasma renin activity. Intraventricularly infused [3H] NE uptake increased in hypothalamus and medulla oblongata of nephrectomized animals in cytoplasmatic compartment as in granular stores, while it decreased in hypothalamus of AII-infused animals. [3H] NE metabolites radioactivity decreased in nephrectomized animals if they are compared with AII-infused ones. These changes were independent of systolic arterial pressure that was not modified in none of the groups. The study of the ratio granular/cytoplasmatic [3H] NE and metabolites radioactivity shows that AII probably acts on cellular membrane uptake of NE. The modification of metabolites/NE ratio in both stores would be due to AII action on MAO activity. The effects of AII and nephrectomy on [3H] NE uptake can explain the inverse relationship between circulating AII levels and NE content in the central nervous system (CNS). |
| Databáze: | OpenAIRE |
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