Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease

Autor:	Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto, Jinta Ochi, Daisuke Takahashi, Tadashi Ueda, Jose M. M. Caaveiro, Yuya Yoshida, Shigehiro Ohdo, Naoya Matsunaga, Shinsuke Toba, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Eiji Kawanishi, Akio Ojida
Rok vydání:	2022
Předmět:	Cysteine Endopeptidases SARS-CoV-2 Drug Discovery Humans Molecular Medicine Protease Inhibitors Cysteine Peptides Antiviral Agents Coronavirus 3C Proteases Peptide Hydrolases COVID-19 Drug Treatment
Zdroj:	Journal of Medicinal Chemistry. 65:13852-13865
ISSN:	1520-4804 0022-2623
Popis:	The coronavirus disease 2019 (COVID-19) pandemic has necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 3C-like protease (3CL
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ea14f9db05b37c0e44c30c65640c72 https://doi.org/10.1021/acs.jmedchem.2c01081 Zobrazit plný text záznamu