Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against ear mite (Otodectes cynotis) infestations in cats
| Autor: | Joe Prullage, Balázs Capári, Julian Liebenberg, Panagiota Ligda, Otsuki Tomoko, Eric Tielemans, Smaragda Sotiraki, Despoina Kostopoulou, Martin Knaus, Michael Ulrich |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Mite Infestations Efficacy Veterinary (miscellaneous) 030231 tropical medicine Otodectes cynotis Eprinomectin Biology Cat Diseases Praziquantel lcsh:Infectious and parasitic diseases 03 medical and health sciences South Africa 0302 clinical medicine medicine Animals lcsh:RC109-216 Ear mite Mites CATS Ivermectin Special Issue – NexGard® Combo (esafoxolaner eprinomectin praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet Cat High effectiveness 030108 mycology & parasitology Afoxolaner biology.organism_classification Dermatology Europe Infectious Diseases Treatment Outcome Insect Science Cats Animal Science and Zoology Parasitology Esafoxolaner After treatment medicine.drug Research Article |
| Zdroj: | Parasite Parasite, Vol 28, p 26 (2021) |
| ISSN: | 1776-1042 |
| Popis: | Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel, nematodicidal and cestodicidal compounds, in NexGard®Combo, a novel topical endectoparasiticide formulation for cats. The efficacy of this formulation was assessed againstOtodectes cynotisin two laboratory studies conducted in South Africa and in the USA with local isolates, and in one field trial conducted in Europe. In each study, cats were randomly allocated to a placebo-treated control group and a novel formulation-treated group. In the laboratory studies, cats were treated at the minimum recommended dose; in the field trial, cats were treated at label dose. All included cats were diagnosed positive forO. cynotisprior to treatment by otoscopy. The main variable of efficacy was a comparison of the number of liveO. cynotiscollected in both ear canals of all cats in the treated and control groups, one month after treatment. Efficacy of the novel topical formulation exceeded 97% in the three studies. These studies demonstrated the high effectiveness of NexGard®Combo in cats for the treatment ofO. cynotisinfestations. No health abnormalities were attributed to the treatment in any of the studies. |
| Databáze: | OpenAIRE |
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