Epstein-Barr Virus (EBV) Genomes and EBV-Encoded Latent Membrane Protein (LMP) in Pulmonary Lymphomas Occurring in Nonimmunocompromised Patients

Autor: Jean-Christophe Sabourin, Marie-Claude Lescs, Elie Serge Zafrani, Panagiotis Kanavaros, Philippe Gaulard, Josette Brière, Tony Petrella
Rok vydání: 1993
Předmět:
Male
Herpesvirus 4
Human
Pathology
Lung Neoplasms
medicine.disease_cause
Lung Neoplasms/*immunology/microbiology/pathology
immune system diseases
hemic and lymphatic diseases
Gammaherpesvirinae
Antigens
Viral
In Situ Hybridization
Immunodeficiency
Viral Matrix Proteins/*analysis
Lymphoma
Non-Hodgkin
Lymphoma
T-Cell/immunology/microbiology/pathology
Middle Aged
medicine.anatomical_structure
RNA
Viral
Immunohistochemistry
Tumor Virus Infections/*immunology/pathology
Anatomy
Immunocompetence
Adult
medicine.medical_specialty
Lymphoma
B-Cell
Biology
Lymphoma
T-Cell
Virus
Herpesviridae
Immunophenotyping
Pathology and Forensic Medicine
Viral Matrix Proteins
Immunocompromised Host
medicine
Humans
Lymphoma
B-Cell/immunology/microbiology/pathology
neoplasms
Aged
Lung
biology.organism_classification
medicine.disease
Epstein–Barr virus
Lymphoma
Tumor Virus Infections
Antigens
Viral/*analysis
RNA
Viral/analysis
Lymphoma
Non-Hodgkin/*immunology/microbiology/pathology
Surgery
Herpesvirus 4
Human/*isolation & purification
Zdroj: The American Journal of Surgical Pathology. 17:995-1002
ISSN: 0147-5185
DOI: 10.1097/00000478-199310000-00004
Popis: Recently, in situ hybridization (ISH) techniques have shown that Epstein-Barr virus (EBV) could be detected in tumor cells of most angiocentric T-cell non-Hodgkin's lymphomas (NHL). These studies included only a few cases of T-NHL of the lung and pulmonary B-NHL and have not been investigated. Furthermore, the expression of the EBV-encoded latent membrane protein (LMP), which is known for its oncogenic properties, has not been reported. Twelve pulmonary NHL (six angiocentric T-NHL and six B-NHL) arising in nonimmunocompromised patients were examined for the presence of EBV-EBER mRNAs and LMP with ISH and immunohistochemistry, respectively. Four cases of pulmonary lymphomas arising in immunocompromised patients were also included in the study for comparison (one T-NHL in a patient under immunosuppressive treatment and three B-NHL in AIDS patients). EBV-RNA and LMP were detected in tumor cells in two of six nonimmunocompromised angiocentric T-NHL and in the four immunocompromised NHL. The six nonimmunocompromised B-NHL were EBV negative. These results suggest that EBV is associated with some angiocentric pulmonary T-NHL arising in patients without overt immunodeficiency whereas it is absent in such patients with B-NHL. The presence of the transforming EBV-encoded LMP in tumor cells suggests that EBV may be involved in the pathogenesis of some pulmonary T-NHL. Am J Surg Pathol
Databáze: OpenAIRE
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