Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review
| Autor: | Amin Shiralizadeh Dezfuli, Hamidreza Pazoki-Toroudi, Abolfazl Akbarzadeh, Bashir Adel, Shaghayegh Askarian-Amiri, Hossein Jafari, Hamidreza Arzaghi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nervous system Cell signaling Scaffold General Neuroscience Regeneration (biology) Cell 02 engineering and technology 021001 nanoscience & nanotechnology Neural tissue engineering 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Tissue engineering medicine Stem cell 0210 nano-technology Neuroscience |
| Zdroj: | Reviews in the Neurosciences. 31:843-872 |
| ISSN: | 2191-0200 0334-1763 |
| DOI: | 10.1515/revneuro-2020-0008 |
| Popis: | The nervous system, which consists of a complex network of millions of neurons, is one of the most highly intricate systems in the body. This complex network is responsible for the physiological and cognitive functions of the human body. Following injuries or degenerative diseases, damage to the nervous system is overwhelming because of its complexity and its limited regeneration capacity. However, neural tissue engineering currently has some capacities for repairing nerve deficits and promoting neural regeneration, with more developments in the future. Nevertheless, controlling the guidance of stem cell proliferation and differentiation is a challenging step towards this goal. Nanomaterials have the potential for the guidance of the stem cells towards the neural lineage which can overcome the pitfalls of the classical methods since they provide a unique microenvironment that facilitates cell–matrix and cell–cell interaction, and they can manipulate the cell signaling mechanisms to control stem cells’ fate. In this article, the suitable cell sources and microenvironment cues for neuronal tissue engineering were examined. Afterward, the nanomaterials that impact stem cell proliferation and differentiation towards neuronal lineage were reviewed. |
| Databáze: | OpenAIRE |
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