Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects
| Autor: | M.L. Zucker, William S. Harris, G.M. Helmkamp, Carlos A. Dujovne, D.S. Bilyeu |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Time Factors Docosahexaenoic Acids Thromboxane Hyperlipoproteinemia Type IV Hyperlipoproteinemia Type II Random Allocation chemistry.chemical_compound Dietary Fats Unsaturated Double-Blind Method Bleeding time Internal medicine Blood plasma medicine Humans Platelet Aged Triglyceride medicine.diagnostic_test business.industry Fibrinolysis Middle Aged Fish oil Lipids Eicosapentaenoic acid Drug Combinations Endocrinology Eicosapentaenoic Acid chemistry Docosahexaenoic acid Fatty Acids Unsaturated Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 73:13-22 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(88)90158-x |
| Popis: | We studied the effects of dietary supplementation with an encapsulated fish oil concentrate (Maxepa) on platelet function, fibrinolysis, and plasma lipids and lipoproteins in 9 normal subjects, 10 patients with type IV hyperlipoproteinemia, and 6 with type IIB hyperlipoproteinemia. After a baseline period, the subjects crossed over randomly between treatment periods with Maxepa (providing 3.24 g eicosapentaenoic acid and 2.16 g docosahexaenoic acid per day) and safflower oil (used as a control), given for 6 weeks each. Administration of Maxepa led to a slight prolongation of the bleeding time in all groups and to modest inhibition of platelet aggregation in the type IV hyperlipoproteinemics and normal subjects, with partial (41%) inhibition of thromboxane synthesis from baseline levels noted in the normal group. Plasma total fibrinolytic actively did not change significantly in any group. Maxepa treatment resulted in a marked decrease in triglyceride and VLDL-cholesterol and a slight increase in HDL-cholesterol was noted after Maxepa in the type IV hyperlipoproteinemics (4.11 +/- 0.13 mmol/l vs. 3.10 +/- 0.16 mmol/l, Maxepa vs. safflower oil). We conclude that dietary supplementation with fish oil results in a relatively minor degree of inhibition of platelet function in normal and hyperlipoproteinemic subjects, and a potentially adverse increase in LDL-cholesterol in type IV hyperlipoproteinemics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|