Novel Insights reveal Anti-microbial Gene Regulation of Piglet Intestine Immune in response to Clostridium perfringens Infection
| Autor: | Sheng Gui Li, Hai Ren Shi, Wenyang Sun, Li Xia Liu, Zun Qiang Yan, Pengfei Wang, Xiao Yu Huang, Shuang Bao Gun, Qiao Li Yang, Sheng Guo Zhao |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Diarrhea Clostridium perfringens Swine animal diseases lcsh:Medicine Inflammation Biology medicine.disease_cause Article Microbiology 03 medical and health sciences 0302 clinical medicine Immune system Ileum medicine Animals RNA Messenger lcsh:Science Regulation of gene expression Swine Diseases Messenger RNA Multidisciplinary Sequence Analysis RNA Gene Expression Profiling lcsh:R RNA Gene expression profiling 030104 developmental biology Gene Expression Regulation Clostridium Infections Cytokines lcsh:Q RNA Long Noncoding medicine.symptom 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) |
| ISSN: | 2045-2322 |
| Popis: | LncRNA play important roles in regulation of host immune and inflammation responses in defending bacterial infection. Clostridium perfringens (C. perfringens) type C is one of primary bacteria leading to piglet diarrhea and other intestinal inflammatory diseases. For the differences of host immune capacity, individuals usually show resistance and susceptibility to bacterial infection. However, whether and how lncRNAs involved in modulating host immune resistance have not been reported. We have investigated the expression patterns of ileum lncRNAs of 7-day-old piglets infected by C. perfringens type C through RNA sequencing. A total of 16 lncRNAs and 126 mRNAs were significantly differentially expressed in resistance (IR) and susceptibility (IS) groups. Many lncRNAs and mRNAs were identified to regulate resistance and susceptibility of piglets through immune related pathways. Five lncRNAs may have potential function on regulating the expressions of cytokines, these lncRNAs and cytokines work together to co-regulated piglet immune response to C. perfringens, affecting host resistance and susceptibility. These results provide valuable information for understanding the functions of lncRNA and mRNA in affecting piglet diarrhea resistance of defensing to C. perfringens type C, these lncRNAs and mRNAs may be used as the important biomarkers for decreasing C. perfringens spread and diseases in human and piglets. |
| Databáze: | OpenAIRE |
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