Effect of Ethanol on Neuronal Activity in The Parietal Association Cortex of Alert Monkeys
| Autor: | Maija Laakso, Helmuth Sippel, Juhani Hyvärinen, Lea Leinonen, Risto O. Roine |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Central nervous system
Action Potentials Stimulation Motor Activity Electroencephalography Somatosensory system 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rhythm Parietal Lobe Cortex (anatomy) Animals Premovement neuronal activity Medicine Skin 030304 developmental biology Neurons 0303 health sciences Ethanol Dose-Response Relationship Drug medicine.diagnostic_test business.industry Haplorhini Somatosensory Cortex medicine.anatomical_structure Biochemistry chemistry Visual Perception Macaca Neurology (clinical) Arousal business Mechanoreceptors Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain. 101:701-715 |
| ISSN: | 1460-2156 0006-8950 |
| DOI: | 10.1093/brain/101.4.701 |
| Popis: | The effect of alcohol was studied in alert monkeys on the cellular mechanisms of the posterior parietal association cortex, a region that normally participates in visuo-spatial co-ordination of hand movements. In thirty-two experiments, the effects of intracardiac administration of ethanol were monitored by the intracortical multiple-unit recording technique. Alcohol produced rhythmic groupings of the spontaneous impulse activity; the rhythm was accentuated by closing the eyes. The dominant frequency of this rhythm (3.5 to 1 Hz) correlated inversely with the blood alcohol level. Three groups of response types were studied in Brodmann's area 7. At 8 of 12 recording sites, a close correlation was observed between the monkey's reaching accuracy and the magnitude of integrate multineuronal responses to reaching with the contralateral arm under visual guidance, or to grasping an object. Half of the 10 recording sites which were activated by complex visual stimulation also showed a close correlation with the behavioural action of alcohol. Least sensitive to alcohol were somatosensory responses; only 3 of 10 of such recording sites were influenced by moderate doses of alcohol. Larger doses producing coma increased the proportion of responses blocked by alcohol, whereas no effects were observed in the adjacent primary somatosensory cortex. Our results show that the posterior parietal association cortex is very sensitive to the action of alcohol. Moreover, these findings support the theory that the action of alcohol in various parts of the central nervous system depends on the complexity of synaptic contacts to the location under study. |
| Databáze: | OpenAIRE |
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