SalmonellaTyphi genomics: envisaging the future of typhoid eradication
| Autor: | Kien-Pong Yap, Kwai Lin Thong |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Salmonella 030106 microbiology Genomics Biology Salmonella typhi medicine.disease_cause Genome Typhoid fever DNA sequencing 03 medical and health sciences Molecular microbiology medicine Humans Typhoid Fever Phylogeny Whole genome sequencing Genetics Typhoid-Paratyphoid Vaccines Public Health Environmental and Occupational Health Drug Resistance Microbial medicine.disease Biological Evolution Virology 030104 developmental biology Infectious Diseases Parasitology Genome Bacterial |
| Zdroj: | Tropical Medicine & International Health. 22:918-925 |
| ISSN: | 1360-2276 |
| Popis: | Next-generation whole-genome sequencing has revolutionised the study of infectious diseases in recent years. The availability of genome sequences and its understanding have transformed the field of molecular microbiology, epidemiology, infection treatments and vaccine developments. We review the key findings of the publicly accessible genomes of Salmonella enterica serovar Typhi since the first complete genome to the most recent release of thousands of Salmonella Typhi genomes, which remarkably shape the genomic research of S. Typhi and other pathogens. Important new insights acquired from the genome sequencing of S. Typhi, pertaining to genomic variations, evolution, population structure, antibiotic resistance, virulence, pathogenesis, disease surveillance/investigation and disease control are discussed. As the numbers of sequenced genomes are increasing at an unprecedented rate, fine variations in the gene pool of S. Typhi are captured in high resolution, allowing deeper understanding of the pathogen's evolutionary trends and its pathogenesis, paving the way to bringing us closer to eradication of typhoid through effective vaccine/treatment development. |
| Databáze: | OpenAIRE |
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