Association of vitamin D receptor gene FokI polymorphism and susceptibility to CAP in Egyptian children: a multicenter study
| Autor: | Mohamed S. Hegab, Mohammed E. Hamed, Ashraf M. Sherif, Mohammed Soliman, Mohammed A. Abdou, Mervat T. Zakaria, Adel M. Abdou, Alsayed Abdel-Aziz, Atef M. Khalil, A.A. Soliman, Amira A. A. Mosabah, Maha A. Noah, Shaimaa S. A. Elashkar, Hany A. A. Elbasyouni, Ghada M. Al-Akad, NourEldin M. Abdelaal, Rehab M. Nabil, Heba Abouzeid |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Calcitriol receptor Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Vitamin D and neurology Humans Medicine Genetic Predisposition to Disease Prospective Studies 030212 general & internal medicine Vitamin D Allele Child Deoxyribonucleases Type II Site-Specific Prospective cohort study Gene Polymorphism Genetic business.industry Case-control study Infant Pneumonia Community-Acquired Infections 030104 developmental biology Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Receptors Calcitriol Egypt Female Restriction fragment length polymorphism business |
| Zdroj: | Pediatric Research. 84:639-644 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/s41390-018-0149-y |
| Popis: | Community-acquired pneumonia (CAP) is the leading cause of child deaths around the world. Recently, the vitamin D receptor (VDR) gene has emerged as a susceptibility gene for CAP. To evaluate the association of the VDR gene Fok I polymorphism with susceptibility to CAP in Egyptian children. This was a multicenter case-control study of 300 patients diagnosed with CAP, and 300 well-matched healthy control children. The VDR Fok I (rs2228570) polymorphism was genotyped by PCR-restriction fragment length polymorphism (RFLP), meanwhile serum 25-hydroxy vitamin D (25D) level was assessed using ELISA method. The frequencies of the VDR FF genotype and F allele were more common in patients with CAP than in our control group (OR = 3.6; (95% CI: 1.9–6.7) for the FF genotype; P = 0.001) and (OR: 1.8; (95% CI: 1.4–2.3) for the F allele; P = 0.01). Patients carrying the VDR FF genotype had lower serum (25D) level (mean; 14.8 ± 3.6 ng/ml) than Ff genotype (20.6 ± 4.5 ng/ml) and the ff genotype (24.5 ± 3.7 ng/ml); P |
| Databáze: | OpenAIRE |
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