Somatic and reflex development in suckling rats: effects of mother treatment with ketogenic diet associated with lack of protein
Autor: | Ana Karla Ferrer Soares, Mylena Lucena de Castro, José Eulálio Cabral-Filho, Angela Amancio-dos-Santos, Renata G.S. Guerra, Rubem Carlos Araújo Guedes, José Audísio Costa, Maria do Carmo Medeiros |
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Rok vydání: | 2009 |
Předmět: |
Male
Aging medicine.medical_specialty Low protein Somatic cell medicine.medical_treatment Medicine (miscellaneous) Biology Weight Gain Pregnancy Protein Deficiency Internal medicine Reflex Diet Protein-Restricted medicine Animals Body Weights and Measures Normal protein Rats Wistar Brain function Nutrition and Dietetics Behavior Animal General Neuroscience Brain maturation Maternal Nutritional Physiological Phenomena General Medicine Animals Suckling Rats Endocrinology Female Diet Ketogenic Ketogenic diet |
Zdroj: | Nutritional Neuroscience. 12:260-266 |
ISSN: | 1476-8305 1028-415X |
DOI: | 10.1179/147683009x423427 |
Popis: | Ketogenic diets influence brain function and have been therapeutically used for anti-epileptic purposes. We investigated the effects of maternal ketogenic diets on the development of somatic and reflex responses in rat pups. These were born from mothers receiving: (i) normal fat (7%) + normal protein (17%); (ii) high-fat (55.4%) + normal protein; (iii) normal fat + low protein (8%); and (iv) high-fat + low protein (respectively, called N-17, K-17, N-8 and K-8). Ketogenic diets, but not the normal-fat diets, delayed the development of reflex and somatic responses. The effects were more evident when the ketogenic diet was associated with low protein content. The results suggest that fat excess can alter brain maturation, and this action is intensified by early protein-deficiency. Data raise concerns about the therapeutic use of ketogenic diets in newborn children. |
Databáze: | OpenAIRE |
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