Systemic and local secretions of cytokines and nitric oxide in massive bowel resected rats with or without small bowel segment reversal
| Autor: | Fu-Ann Tsai, Hsiu-Fen Wang, Su-Chen Lin, Hui-Chen Lo |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Nitrogen medicine.medical_treatment Immunology Biology Nitric Oxide Biochemistry Gastroenterology Nitric oxide chemistry.chemical_compound Cecum Interferon-gamma Internal medicine Intestine Small medicine Immunology and Allergy Animals Rats Wistar Molecular Biology Lung Interleukin-6 Tumor Necrosis Factor-alpha Body Weight Interleukin Proteins Hematology Bowel resection Blood Proteins Feeding Behavior Organ Size Hyperplasia medicine.disease Blood proteins Small intestine Surgery Rats medicine.anatomical_structure chemistry Liver Cytokines Interleukin-2 Tumor necrosis factor alpha |
| Zdroj: | Cytokine. 14(2) |
| ISSN: | 1043-4666 |
| Popis: | Our previous study suggested that small bowel segment reversal stimulates jejunal hyperplasia, but that the elevated serum interleukin (IL-)6 eliminates whole-body anabolism in massive bowel resected rats. The aim of this study was to investigate systemic and local secretions of cytokines and nitric oxide (NO) in relation to whole-body and tissue responses in rats that underwent massive bowel resection with small bowel segment reversal. Seventy percent small bowel resection was performed in Wistar rats with (REV) or without (CON) a 5 cm reversed small bowel segment. Sham operation (SHAM) was performed on a third group of rats. Twelve days after surgery the REV group had significantly lower weight gain and greater serum levels of NO, IL-2 and IL-6 than the CON and SHAM groups. The weights of the livers in the REV and CON groups were significantly heavier, but these groups had lower levels of protein, tumour-necrosis factor-alpha, IL-2 and IL-6 than the SHAM group. The cecum weights of the REV group were significantly higher with increased protein and NO levels, but decreased IL-6 levels compared with the CON and SHAM groups. In the proximal small intestine the REV group had significantly increased protein levels and mucosal dry weights, but decreased interferon-gamma and IL-2 compared with the CON and SHAM groups. Our results suggested that cytokines and NO may have endocrine and paracrine/autocrine actions in regulating whole-body and tissue responses. |
| Databáze: | OpenAIRE |
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