CURB-65 plus Hypoalbuminemia: a new score system for prediction of the in-hospital mortality risk in patients with SARS-CoV-2 pneumonia
| Autor: | F. Cancelli, Giancarlo Ceccarelli, Gabriella d'Ettorre, Claudio Maria Mastroianni, T. Bucci, Alessandra Oliva, G. Galardo, Cristian Borrazzo, Ambrogio Curtolo, Francesco Pugliese, D. A. Ismail, Maria Teresa Mascellino, Mario Venditti |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hypoalbu-minemia extended CURB-65 law.invention law Internal medicine medicine Risk of mortality In patient Hypoalbuminemia CURB-65 ICU admission In hospital mortality business.industry Original Articles medicine.disease Intensive care unit mortality CALL score CRP PSI score Pneumonia Infectious Diseases business |
| Zdroj: | Infez Med |
| Popis: | Introduction: There is the need of a simple but highly reliable score system for stratifying the risk of mortality and Intensive Care Unit (ICU) transfer in patients with SARS-CoV-2 pneumonia at the Emergency Room. Purpose: In this study, the ability of CURB-65, extended CURB-65, PSI and CALL scores and C-Reactive Protein (CRP) to predict intra-hospital mortality and ICU admission in patients with SARS-CoV-2 infection were evaluated.Methods: During March-May 2020, a retrospective, single-center study including all consecutive adults patients with diagnosis of SARS-CoV-2 pneumonia was conducted. Clinical, laboratory and radiological data as well as CURB-65, expanded CURB-65, PSI and CALL scores were calculated based on data recorded at hospital admission. Results: Overall, 224 patients with documented SARS-CoV-2 infection were included in the study. As for intra-hospital mortality (24/224, 11%), PSI performed better than all the other tested scores, which showed lower AUC values (AUC=0.890 for PSI versus AUC=0.885, AUC=0.858 and AUC=0.743 for expanded CURB-65, CURB-65 and CALL scores, respectively). Of note, the addition of hypoalbuminemia to the CURB-65 score increased the prediction value of intra-hospital mortality (AUC=0.905). All the tested scores performed worse in predicting the need of ICU transfer (26/224, 12%), with the best AUC for extended CURB-65 score (AUC= 0.708).Conclusion: The addition of albumin level to the easy-to-calculate CURB-65 score at hospital admission is able to improve the quality of prediction of intra-hospital mortality in patients with SARS-CoV-2 pneumonia. |
| Databáze: | OpenAIRE |
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