Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy
| Autor: | Ashok Kumar, Sushil Kumar Singh, Supraja Siddamurthi, Srabanti Jana, Gopichand Gutti |
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| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Telomerase Cancer therapy Anthraquinones Antineoplastic Agents 01 natural sciences 03 medical and health sciences Drug Development Neoplasms Drug Discovery Humans Medicine Enzyme Inhibitors Cell Proliferation 030304 developmental biology Cause of death Pharmacology Biological Products 0303 health sciences biology business.industry Kinase Topoisomerase Cancer DNA Neoplasm medicine.disease 0104 chemical sciences 010404 medicinal & biomolecular chemistry Cancer research biology.protein Molecular Medicine business |
| Zdroj: | Future Medicinal Chemistry. 12:1037-1069 |
| ISSN: | 1756-8927 1756-8919 |
| DOI: | 10.4155/fmc-2019-0198 |
| Popis: | Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in both advanced and emerging countries. Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe. Natural anthraquinone (AQ) equivalents such as emodin, aloe-emodin, alchemix and many synthetic analogs extend their antitumor activity on different targets including telomerase, topoisomerases, kinases, matrix metalloproteinases, DNA and different phases of cell lines. Nano drug delivery strategies are advanced tools which deliver drugs into tumor cells with minimum drug leakage to normal cells. This review delineates the way AQ derivatives are binding on these targets by abolishing tumor cells to produce anticancer activity and purview of nanoformulations related to AQ analogs. |
| Databáze: | OpenAIRE |
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