Hereditary Hemolytic Anemia with Hexokinase Deficiency
| Autor: | J L Naiman, Arthur S. Schneider, Donald E. Paglia, F A Oski, William N. Valentine, Marjorie A. Baughan |
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| Rok vydání: | 1967 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Erythrocytes Thalassemia Oxidative phosphorylation Biology Pentose phosphate pathway Anemia Hemolytic Congenital Hereditary Hemolytic Anemia chemistry.chemical_compound Hexokinase Internal medicine Leukocytes medicine Humans Carbon Isotopes Infant Erythrocyte Aging General Medicine medicine.disease Blood Cell Count Hexokinase deficiency Glucose Hemoglobinopathy Endocrinology chemistry Biochemistry Spectrophotometry Hemoglobinometry Female NAD+ kinase |
| Zdroj: | New England Journal of Medicine. 276:1-11 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm196701052760101 |
| Popis: | IT is now clear that hereditary hemolytic anemias not associated with hemoglobinopathy or with the thalassemia syndromes are frequently due to inherited deficiencies in one or another of the enzymes upon which the erythrocyte is dependent to meet its energy needs. The non-nucleated, relatively metabolically impoverished adult human red cell has limited resources and places major dependence upon energy derived from the conversion of glucose to lactate – chiefly via the anaerobic Embden–Meyerhof pathway, but to a lesser but still important extent by way of the oxidative hexose monophosphate shunt. In the former diphosphopyridine nucleotide (NAD) is cycled to its . . . |
| Databáze: | OpenAIRE |
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