CD11b expression identifies CD8+CD28+ T lymphocytes with phenotype and function of both naive/memory and effector cells
| Autor: | Monica Bonafede, Silvio Caligaris, Emirena Garrafa, Arnaldo Caruso, Andrea Balsari, Manuela Grassi, S. Licenziati, Giulio Alessandri, Francesco Castelli, Simona Fiorentini, Adolfo Turano |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Cytotoxicity
Immunologic Pore Forming Cytotoxic Proteins CD8 Antigens Immunology Macrophage-1 Antigen chemical and pharmacologic phenomena Biology CD8-Positive T-Lymphocytes Lymphocyte Activation Cell Line Immunophenotyping Chickenpox CD28 Antigens Cell Movement T-Lymphocyte Subsets Cell Adhesion Immunology and Allergy Humans Infectious Mononucleosis Phytohemagglutinins Interphase Membrane Glycoproteins Effector Perforin CD28 hemic and immune systems Cell Differentiation Cell biology Cytolysis Chemotaxis Leukocyte Cell culture T cell differentiation biology.protein Cytokines Interleukin-2 Endothelium Vascular Immunologic Memory CD8 Measles |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 166(2) |
| ISSN: | 0022-1767 |
| Popis: | A previously unreported CD8+CD28+CD11b+ T cell subset occurs in healthy individuals and expands in patients suffering from primary viral infections. In functional terms, these cells share the features of naive/memory CD8+CD28+CD11b− and terminally differentiated effector CD8+CD28−CD11b+ subpopulations. Like CD28− cells, CD28+CD11b+ lymphocytes have the ability to produce IFN-γ, to express perforin granules in vivo, and to exert a potent cytolytic activity. Moreover, these cells can respond to chemotactic stimuli and can efficiently cross the endothelial barrier. In contrast, like their CD11b− counterpart, they still produce IL-2 and retain the ability to proliferate following mitogenic stimuli. The same CD28+CD11b+ subpopulation detected in vivo could be generated by culturing naive CD28+CD11b− cells in the presence of mitogenic stimuli following the acquisition of a CD45RO+ memory phenotype. Considering both phenotypic and functional properties, we argue that this subset may therefore constitute an intermediate phenotype in the process of CD8+ T cell differentiation and that the CD11b marker expression can distinguish between memory- and effector-type T cells in the human CD8+CD28+ T cell subset. |
| Databáze: | OpenAIRE |
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