Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia
| Autor: | Jochen Harbott, Martin Stanulla, Susanne Viehmann, Martin Schrappe, Bernard M. Fine, Linda M. Boxer, Minh Ho |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Adolescent Oncogene Proteins Fusion Immunology Gene Expression Chromosomal translocation Genes abl Biology Biochemistry Translocation Genetic Cell Line Tumor hemic and lymphatic diseases Acute lymphocytic leukemia Proto-Oncogenes Receptors Erythropoietin medicine Humans Child neoplasms Gene ABL Base Sequence Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Infant Newborn breakpoint cluster region Infant DNA Neoplasm Histone-Lysine N-Methyltransferase Cell Biology Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Molecular biology DNA-Binding Proteins Gene expression profiling Child Preschool Core Binding Factor Alpha 2 Subunit Chromosome abnormality Cancer research Myeloid-Lymphoid Leukemia Protein Female Transcription Factors |
| Zdroj: | Blood. 103:1043-1049 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2003-05-1518 |
| Popis: | We obtained a global view of gene expression in both cell lines and pediatric acute lymphoblastic leukemia (ALL) samples that harbor one of several selected chromosomal abnormalities. When the cell lines were studied alone, we found that these chromosomal abnormalities were associated with the predominant variation in transcriptional programs across the set of cell lines studied. When cell lines and clinical samples were studied together, we found that each chromosomal abnormality (TEL/AML1, BCR/ABL, or MLL abnormalities) was associated with a characteristic gene expression signature that was shared by both cell lines and clinical samples. However, BCR/ABL was associated with a much more heterogeneous pattern of expression than were TEL/AML1 and MLL abnormalities. This observation has important implications for the study of BCR/ABL ALL. In addition, we systematically identified genes whose expression was associated with TEL/AML1, BCR/ABL, or MLL abnormalities in both clinical samples and cell lines. Although some of these genes have previously been described, many have not previously been reported to be associated with one of these chromosomal abnormalities. Notably, we found that the erythropoietin receptor (EPOR) is consistently highly expressed in TEL/AML1 ALL compared with BCR/ABL or MLL. (Blood. 2004;103:1043-1049) |
| Databáze: | OpenAIRE |
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