Solitary fibrous tumor of the pleura: Can computed tomography features help predict malignancy? A series of 56 patients with histopathological correlates
| Autor: | Marco Alifano, S. Hélage, François Laurent, Gilbert Ferretti, Audrey Mansuet-Lupo, Etienne Audureau, Marie-Pierre Revel, M.-L. Chabi, Dominique Vadrot, J.-N. Buy |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Solitary fibrous tumor medicine.medical_specialty Pleural effusion Pleural Neoplasms Malignancy Asymptomatic 03 medical and health sciences 0302 clinical medicine Iodinated contrast Predictive Value of Tests medicine Humans Radiology Nuclear Medicine and imaging Pleural Neoplasm Aged Retrospective Studies Aged 80 and over Radiological and Ultrasound Technology business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Solitary Fibrous Tumor Pleural 030228 respiratory system 030220 oncology & carcinogenesis Predictive value of tests Female Radiology medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Diagnostic and Interventional Imaging. 97:347-353 |
| ISSN: | 2211-5684 |
| DOI: | 10.1016/j.diii.2015.04.013 |
| Popis: | Objective To identify computed tomography (CT) predictors of malignancy, from a retrospective study of preoperative CT scans of patients with solitary fibrous tumors (SFT) of the pleura. Patients and methods The CT scans of 56 patients with histopathologically confirmed SFT (33 women and 23 men; mean age, 60 years) who underwent surgery between December 2004 and November 2012 were retrospectively analyzed by three radiologists working in consensus, blinded to the final histological diagnosis. Results SFT was asymptomatic and incidentally discovered in 22 patients (45.8%). Resection specimen analysis (R0 resection in all cases) revealed that 23 tumors (41%) were malignant. The CT features, which significantly differed between malignant and benign SFTs were tumor size ( P = 0.002) with a discriminative threshold value of 10 cm, tumor heterogeneity before ( P = 0.02) and after ( P = 0.03) intravenous administration of iodinated contrast material, presence of intratumoral hydric attenuation areas ( P = 0.01), pleural effusion ( P = 0.01), measurable intratumoral vessels ( P = 0.02), hypervascularization with visible intratumoral vessels and/or marked enhancement ( P = 0.001). Presence of intratumoral calcifications ( P = 0.2) and maximum post-contrast enhancement value ( P = 0.6) were not significantly different between the two groups. Conclusion A size greater than or equal to 10 cm, hypervascularization, attenuation heterogeneity and association with pleural effusion are individual variables that suggest malignant SFT on CT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect