Concordant acute myeloblastic leukemia in identical twins treated with allogeneic transplantation from a younger HLA-identical sibling following a single apheresis procedure
| Autor: | David Gómez-Almaguer, Yajaira Valentine Jimenez-Antolinez, Ileana Yazmín Velasco Ruiz, Elias Eugenio Gonzalez-Lopez, Oscar González-Llano, Marcela Cantu-Moreno |
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| Rok vydání: | 2021 |
| Předmět: |
measurable residual disease
medicine.medical_specialty Allogeneic transplantation Acute myeloblastic leukemia bone marrow transplantation Case Report infant acute leukemia Human leukocyte antigen single apheresis Gastroenterology hemic and lymphatic diseases Internal medicine medicine matched sibling donor Pharmacology (medical) Sibling younger donor business.industry concordant leukemia Myeloid leukemia peripheral blood stem cell twins Hematology medicine.disease Minimal residual disease myelodysplastic syndrome Leukemia surgical procedures operative Oncology Monoclonal business |
| Zdroj: | International Journal of Hematologic Oncology |
| ISSN: | 2045-1407 2045-1393 |
| Popis: | A concordant leukemia is that which occurs in a pair of monozygotic twins; a similar genetic background suggests an in utero monoclonal origin. We present the case of a pair of monozygotic infants with concordant acute myeloid leukemia who underwent a peripheral blood hematopoietic stem-cell transplant (HSCT) from a single, younger human leukocyte antigen-identical sibling donor, using a fractioned graft collected during only one apheresis procedure. Twin A relapsed at +456 and received a second haploidentical HSCT from his father, twin B has been in complete remission since the first HSCT. Both children are in complete remission and with negative minimal residual disease at +900 (after second transplant) and +1488, respectively. |
| Databáze: | OpenAIRE |
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