Intraabdominal Desmoplastic Small Round Cell Tumor Presenting as a Gastric Mural Mass With Hepatic Metastases
| Autor: | Hicks Mj, Trautwein Lm, Jeffrey C. Murray, Claire Langston, Paul K. Minifee, Morad Ab |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Pathology Abdominal pain Vincristine Desmoplastic small-round-cell tumor medicine.medical_treatment Stomach Neoplasms Laparotomy Antineoplastic Combined Chemotherapy Protocols Ascites Biopsy medicine Humans Child Cyclophosphamide medicine.diagnostic_test business.industry Liver Neoplasms Combination chemotherapy Hematology medicine.disease Combined Modality Therapy medicine.anatomical_structure Oncology Doxorubicin Abdominal Neoplasms Pediatrics Perinatology and Child Health Abdomen Radiology medicine.symptom Tomography X-Ray Computed business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 18:289-292 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/00043426-199608000-00011 |
| Popis: | Purpose: An atypical case of childhood intraabdominal desmoplastic small round cell tumor (DSRCT) is presented. Patient and Methods: An 11-year-old boy presented with progressive nausea and vomiting, abdominal pain, hepatomegaly, and an epigastric mass. Computed tomographic scanning as well as findings at gastroscopy and laparotomy revealed a large gastric mural tumor accompanied by multiple large intrahepatic masses. Histopathologic examination of biopsy samples revealed evidence of a polyphenotypic neoplasm diagnostic of DSRCT. Results: Unlike most reported cases of DSRCT, no evidence of peritoneal involvement or ascites was detected. Despite an excellent initial response to multiagent chemotherapy, the patient eventualy died of progressive tumor. Conclusions: Though the radiographic and surgical findings in DSRCT usually suggest a mesenteric, peritoneal, or retroperitoneal site of tumor origin, this case demonstrates that intraabdominal DSRCT can present with a primary visceral lesion without evidence of peritoneal or mesenteric involvement or ascites. Combination chemotherapy using vincristine, doxorubicin, cyclophosphamide, cisplatin, and 5-fluorouracil may be of some benefit to patients with this rare tumor. |
| Databáze: | OpenAIRE |
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