Reduced fractional anisotropy in projection, association, and commissural fiber networks in neonates with prenatal methamphetamine exposure
| Autor: | Andre van der Kouwe, Christopher D. Molteno, Paul A. Taylor, Sandra W. Jacobson, Ernesta M. Meintjes, Joseph L. Jacobson, Lilla Zöllei, Christopher M. R. Warton, Fleur L. Warton, Pia Wintermark |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Neuroimaging Biology Article Methamphetamine White matter 03 medical and health sciences Cellular and Molecular Neuroscience Association fiber 0302 clinical medicine Developmental Neuroscience Pregnancy Internal medicine Image Interpretation Computer-Assisted Neural Pathways Fractional anisotropy medicine Humans Projection (set theory) Prenatal methamphetamine exposure Infant Newborn Brain Magnetic Resonance Imaging White Matter 030104 developmental biology medicine.anatomical_structure Prenatal Exposure Delayed Effects Cardiology Anisotropy Central Nervous System Stimulants Female Commissural fiber 030217 neurology & neurosurgery Diffusion MRI medicine.drug |
| Zdroj: | Dev Neurobiol |
| ISSN: | 1932-846X 1932-8451 |
| DOI: | 10.1002/dneu.22784 |
| Popis: | Prenatal exposure to methamphetamine is associated with neurostructural changes, including alterations in white matter microstructure. This study investigated the effects of methamphetamine exposure on microstructure of global white matter networks in neonates. Pregnant women were interviewed beginning in mid-pregnancy regarding their methamphetamine use. Diffusion weighted imaging sets were acquired for 23 non-sedated neonates. White matter bundles associated with pairs of target regions within five networks (commissural fibres, left and right projection fibres, and left and right association fibres) were estimated using probabilistic tractography, and fractional anisotropy (FA) and diffusion measures determined within each connection. Multiple regression analyses showed that increasing methamphetamine exposure was significantly associated with reduced FA in all five networks, after control for potential confounders. Increased exposure was associated with lower axial diffusivity in the right association fibre network and with increased radial diffusivity in the right projection and left and right association fibre networks. Within the projection and association networks a subset of individual connections showed a negative correlation between FA and methamphetamine exposure. These findings are consistent with previous reports in older children and demonstrate that microstructural changes associated with methamphetamine exposure are already detectable in neonates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text