High rate of abnormal blood values and vascular complications before diagnosis of myeloproliferative neoplasms
| Autor: | Marie Bak, Hans Carl Hasselbalch, Jennifer Tetu, Bjorn Andreasson, François Girodon, Emma Lindskog, Ditte Hersby, Anneli Enblom |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Gastrointestinal bleeding Denmark Deep vein Gastroenterology Hemoglobins Leukocyte Count Internal medicine Internal Medicine medicine Humans Blood test Myeloproliferative neoplasm Aged Retrospective Studies Aged 80 and over Sweden Myeloproliferative Disorders medicine.diagnostic_test Platelet Count business.industry food and beverages Middle Aged medicine.disease Thrombosis Surgery Pulmonary embolism medicine.anatomical_structure Hematocrit Splanchnic vein thrombosis Embolism Cardiovascular Diseases Female France business |
| Zdroj: | European Journal of Internal Medicine. 26:344-347 |
| ISSN: | 0953-6205 |
| DOI: | 10.1016/j.ejim.2015.03.009 |
| Popis: | Background Vascular complications occurring before the diagnosis of myeloproliferative neoplasms (MPN) in 612 patients from four centers in Sweden, Denmark and France were retrospectively studied. Results Vascular complications were observed in 151 (25%) of the 612 patients. Of these, 66% occurred during the two years preceding diagnosis. The majority of events were thromboembolic (95%), and included myocardial infarction (n = 46), ischemic stroke (n = 43), transient ischemic attack (TIA) (n = 22), deep vein thrombosis/pulmonary embolism (n = 19), splanchnic vein thrombosis (n = 7), and peripheral embolism (n = 7). Bleeding was observed in only 7 (5%) of the 151 patients with vascular events (3 with intracranial bleeding, 2 with epistaxis and 2 with gastrointestinal bleeding). Full blood counts obtained at least 3 months prior to the MPN diagnosis showed that 269 (44%) had abnormal blood values, fulfilling the diagnostic criteria for MPN. During the time from the abnormal blood test to the diagnosis of MPN, 50 patients suffered from a vascular complication. Conclusion We therefore conclude that a large proportion of MPN patients suffer severe thromboembolic complications prior to diagnosis. If MPN were diagnosed earlier, a large proportion of these events might be prevented. An MPN should always be suspected and ruled out in patients with unexplained elevated hematocrit, leukocyte and/or platelet counts. |
| Databáze: | OpenAIRE |
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