Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides

Autor:	Sergey N. Kochetkov, Marina A. Zenkova, Evgeniya B. Logashenko, Anna A. Klimenko, Anastasia L. Khandazhinskaya, Pavel N. Solyev, Elena S. Matyugina
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	structure–activity relationship Pyrimidine Stereochemistry Cell Survival Substituent Pharmaceutical Science Antineoplastic Agents antiproliferative properties 010402 general chemistry Ring (chemistry) 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Mice Structure-Activity Relationship lcsh:Organic chemistry Cell Line Tumor Drug Discovery Structure–activity relationship Animals Humans Physical and Theoretical Chemistry Cell Proliferation Bicyclic molecule Molecular Structure 010405 organic chemistry Organic Chemistry Biological activity 0104 chemical sciences Pyrimidines chemistry Chemistry (miscellaneous) A549 Cells Molecular Medicine 5′-norcarbocyclic nucleoside analogues Selectivity Lead compound HeLa Cells
Zdroj:	Molecules Volume 23 Issue 10 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules, Vol 23, Iss 10, p 2654 (2018)
ISSN:	1420-3049
DOI:	10.3390/molecules23102654
Popis:	Here we report the synthesis and biological activity of new 5&prime norcarbocyclic derivatives of bicyclic pyrrolo- and furano[2,3-d]pyrimidines with different substituents in the heterocyclic ring. Lead compound 3i, containing 6-pentylphenyl substituent, displays inhibitory activity with respect to a number of tumor cells with a moderate selectivity index value. Compound 3i induces cell death by the apoptosis pathway with the dissipation of mitochondrial potential.
Databáze:	OpenAIRE
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