Common Factors of Alzheimer’s Disease and Rheumatoid Arthritis—Pathomechanism and Treatment
| Autor: | Jarosław Dudka, Paulina Trzeciak, Mariola Herbet |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
rheumatoid arthritis
Aging Systemic disease Amyloid Pharmaceutical Science Plaque Amyloid Review Disease Analytical Chemistry Arthritis Rheumatoid Pathogenesis QD241-441 Immune system Alzheimer Disease Drug Discovery medicine Humans Physical and Theoretical Chemistry business.industry Amyloidosis Organic Chemistry Brain amyloid Parkinson Disease medicine.disease immune system Blood-Brain Barrier Chemistry (miscellaneous) Rheumatoid arthritis Immunology Cytokines Molecular Medicine Cholinergic business Alzheimer’s disease |
| Zdroj: | Molecules, Vol 26, Iss 6038, p 6038 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | The accumulation of amyloid plaques, or misfolded fragments of proteins, leads to the development of a condition known as amyloidosis, which is clinically recognized as a systemic disease. Amyloidosis plays a special role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease, and rheumatoid arthritis (RA). The occurrence of amyloidosis correlates with the aging process of the organism, and since nowadays, old age is determined by the comfort of functioning and the elimination of unpleasant disease symptoms in the elderly, exposure to this subject is justified. In Alzheimer’s disease, amyloid plaques negatively affect glutaminergic and cholinergic transmission and loss of sympathetic protein, while in RA, amyloids stimulated by the activity of the immune system affect the degradation of the osteoarticular bond. The following monograph draws attention to the over-reactivity of the immune system in AD and RA, describes the functionality of the blood–brain barrier as an intermediary medium between RA and AD, and indicates the direction of research to date, focusing on determining the relationship and the cause–effect link between these disorders. The paper presents possible directions for the treatment of amyloidosis, with particular emphasis on innovative therapies. |
| Databáze: | OpenAIRE |
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