Serologic features of cohorts with variable genetic risk for systemic lupus erythematosus
| Autor: | Cynthia Aranow, Ogobara K. Doumbo, Bahtiyar Toz, Karalyn Pappas, Meggan Mackay, Martin Lesser, Maureen McMahon, Michael H. Weisman, Tammy O. Utset, Deborah M. Levy, Betty Diamond, Daniel J. Wallace, Juanita Romero-Diaz, W J McCune, Peter K. Gregersen, Meenakshi Jolly, Earl D. Silverman, A K Traoré, Jyotsna Bhattacharya |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Adolescent Black People Disease White People Serology lcsh:Biochemistry 03 medical and health sciences Young Adult immune system diseases Internal medicine Genetics medicine Humans Lupus Erythematosus Systemic lcsh:QD415-436 Genetic Predisposition to Disease Young adult skin and connective tissue diseases Molecular Biology Genetics (clinical) Aged Autoimmune disease Lupus erythematosus Systemic lupus erythematosus business.industry Incidence (epidemiology) Complement C1q lcsh:RM1-950 Middle Aged medicine.disease Malaria 030104 developmental biology lcsh:Therapeutics. Pharmacology Immunoglobulin M Antibodies Antinuclear Immunoglobulin G Molecular Medicine Female business Nephritis Research Article |
| Zdroj: | Molecular Medicine, Vol 24, Iss 1, Pp 1-7 (2018) Molecular Medicine |
| ISSN: | 1528-3658 |
| Popis: | Background Systemic lupus erythematosus (SLE) is an autoimmune disease with genetic, hormonal, and environmental influences. In Western Europe and North America, individuals of West African descent have a 3–4 fold greater incidence of SLE than Caucasians. Paradoxically, West Africans in sub-Saharan Africa appear to have a low incidence of SLE, and some studies suggest a milder disease with less nephritis. In this study, we analyzed sera from African American female SLE patients and four other cohorts, one with SLE and others with varying degrees of risk for SLE in order to identify serologic factors that might correlate with risk of or protection against SLE. Methods Our cohorts included West African women with previous malaria infection assumed to be protected from development of SLE, clinically unaffected sisters of SLE patients with high risk of developing SLE, healthy African American women with intermediate risk, healthy Caucasian women with low risk of developing SLE, and women with a diagnosis of SLE. We developed a lupus risk index (LRI) based on titers of IgM and IgG anti-double stranded DNA antibodies and levels of C1q. Results The risk index was highest in SLE patients; second highest in unaffected sisters of SLE patients; third highest in healthy African-American women and lowest in healthy Caucasian women and malaria-exposed West African women. Conclusion This risk index may be useful in early interventions to prevent SLE. In addition, it suggests new therapeutic approaches for the treatment of SLE. |
| Databáze: | OpenAIRE |
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