Emergence of methicillin resistance predates the clinical use of antibiotics

Autor: Jesper Larsen, Claire L. Raisen, Xiaoliang Ba, Nicholas J. Sadgrove, Guillermo F. Padilla-González, Monique S. J. Simmonds, Igor Loncaric, Heidrun Kerschner, Petra Apfalter, Rainer Hartl, Ariane Deplano, Stien Vandendriessche, Barbora Černá Bolfíková, Pavel Hulva, Maiken C. Arendrup, Rasmus K. Hare, Céline Barnadas, Marc Stegger, Raphael N. Sieber, Robert L. Skov, Andreas Petersen, Øystein Angen, Sophie L. Rasmussen, Carmen Espinosa-Gongora, Frank M. Aarestrup, Laura J. Lindholm, Suvi M. Nykäsenoja, Frederic Laurent, Karsten Becker, Birgit Walther, Corinna Kehrenberg, Christiane Cuny, Franziska Layer, Guido Werner, Wolfgang Witte, Ivonne Stamm, Paolo Moroni, Hannah J. Jørgensen, Hermínia de Lencastre, Emilia Cercenado, Fernando García-Garrote, Stefan Börjesson, Sara Hæggman, Vincent Perreten, Christopher J. Teale, Andrew S. Waller, Bruno Pichon, Martin D. Curran, Matthew J. Ellington, John J. Welch, Sharon J. Peacock, David J. Seilly, Fiona J. E. Morgan, Julian Parkhill, Nazreen F. Hadjirin, Jodi A. Lindsay, Matthew T. G. Holden, Giles F. Edwards, Geoffrey Foster, Gavin K. Paterson, Xavier Didelot, Mark A. Holmes, Ewan M. Harrison, Anders R. Larsen
Přispěvatelé: Larsen, Jesper [0000-0003-0582-0457], Ba, Xiaoliang [0000-0002-3882-3585], Padilla-González, Guillermo F [0000-0002-8300-6891], Černá Bolfíková, Barbora [0000-0001-8059-4889], Skov, Robert L [0000-0002-6079-5381], Rasmussen, Sophie L [0000-0002-2975-678X], Espinosa-Gongora, Carmen [0000-0002-9536-0548], Aarestrup, Frank M [0000-0002-7116-2723], Becker, Karsten [0000-0002-6391-1341], Layer, Franziska [0000-0002-4613-6478], Moroni, Paolo [0000-0002-0974-3084], Jørgensen, Hannah J [0000-0002-1788-9219], de Lencastre, Hermínia [0000-0001-6816-8932], Cercenado, Emilia [0000-0002-5279-3773], Börjesson, Stefan [0000-0003-2219-2659], Waller, Andrew S [0000-0002-7111-9549], Welch, John [0000-0001-7049-7129], Peacock, Sharon [0000-0002-1718-2782], Morgan, Fiona [0000-0003-0583-7996], Parkhill, Julian [0000-0002-7069-5958], Holden, Matthew TG [0000-0002-4958-2166], Foster, Geoffrey [0000-0002-5527-758X], Paterson, Gavin K [0000-0002-1880-0095], Didelot, Xavier [0000-0003-1885-500X], Holmes, Mark [0000-0002-5454-1625], Harrison, Ewan [0000-0003-2720-0507], Apollo - University of Cambridge Repository, Peacock, Sharon J [0000-0002-1718-2782], Holmes, Mark A [0000-0002-5454-1625], Harrison, Ewan M [0000-0003-2720-0507], University of St Andrews. School of Medicine, University of St Andrews. Biomedical Sciences Research Complex, University of St Andrews. St Andrews Bioinformatics Unit, University of St Andrews. Infection and Global Health Division
Rok vydání: 2022
Předmět:
Denmark
Geographic Mapping
Methicillin Resistance/genetics
Antimicrobial resistance
Bacterial evolution
Penicillins/biosynthesis
Phylogeny
beta-Lactams/metabolism
Multidisciplinary
630 Agriculture
article
QR Microbiology
Anti-Bacterial Agents
Europe
Hedgehogs
Hedgehogs/metabolism
Methicillin-Resistant Staphylococcus aureus
631/326/41/2529
45/22
45/23
101/58
Anti-Bacterial Agents/history
Penicillins
beta-Lactams
Selection
Genetic/genetics
Evolution
Molecular
SDG 3 - Good Health and Well-being
631/92/349/977
631/158/1745
Animals
Humans
One Health
Selection
Genetic
SDG 2 - Zero Hunger
MCC
Infectious-disease epidemiology
QL
Arthrodermataceae/genetics
Arthrodermataceae
DAS
500 Naturwissenschaften und Mathematik::570 Biowissenschaften
Biologie::570 Biowissenschaften
Biologie
History
20th Century
QR
631/326/41/1470
631/326/22/1434
570 Life sciences
biology
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus/genetics
New Zealand
Zdroj: Larsen, Jesper; Raisen, Claire L; Ba, Xiaoliang; Sadgrove, Nicholas J; Padilla-González, Guillermo F; Simmonds, Monique S J; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, Ariane; Vandendriessche, Stien; Černá Bolfíková, Barbora; Hulva, Pavel; Arendrup, Maiken C; Hare, Rasmus K; Barnadas, Céline; Stegger, Marc; Sieber, Raphael N; Skov, Robert L; ... (2022). Emergence of methicillin resistance predates the clinical use of antibiotics. Nature, 602(7895), pp. 135-141. Springer Nature Limited 10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Ariane Deplano, A, Vandendriessche, S, Bolfíková, B Č, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L, Nykäsenoja, S, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, J. Teale, C, Waller, A, Pichon, B, Curran, M, Ellington, M, Welch, J, Peacock, S, Seilly, D, Morgan, F, Parkhill, J, Hadjirin, N, Lindsay, J, Holden, M T G, Edwards, G F, Foster, G, Paterson, G, Didelot, X, Holmes, M, Harrison, E & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, no. 7895, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w
Larsen, J, Raisen, C L, Ba, X, Sadgrove, N J, Padilla-González, G F, Simmonds, M S J, Loncaric, I, Kerschner, H, Apfalter, P, Hartl, R, Deplano, A, Vandendriessche, S, Černá Bolfíková, B, Hulva, P, Arendrup, M C, Hare, R K, Barnadas, C, Stegger, M, Sieber, R N, Skov, R L, Petersen, A, Angen, Ø, Rasmussen, S L, Espinosa-Gongora, C, Aarestrup, F M, Lindholm, L J, Nykäsenoja, S M, Laurent, F, Becker, K, Walther, B, Kehrenberg, C, Cuny, C, Layer, F, Werner, G, Witte, W, Stamm, I, Moroni, P, Jørgensen, H J, de Lencastre, H, Cercenado, E, García-Garrote, F, Börjesson, S, Hæggman, S, Perreten, V, Teale, C J, Waller, A S, Pichon, B, Curran, M D, Ellington, M J, Welch, J J, Peacock, S J, Seilly, D J, Morgan, F J E, Parkhill, J, Hadjirin, N F, Lindsay, J A, Holden, M T G, Edwards, G F, Foster, G, Paterson, G K, Didelot, X, Holmes, M A, Harrison, E M & Larsen, A R 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135–141 . https://doi.org/10.1038/s41586-021-04265-w
Paterson, G K 2022, ' Emergence of methicillin resistance predates the clinical use of antibiotics ', Nature, vol. 602, pp. 135-141 . https://doi.org/10.1038/s41586-021-04265-w
ISSN: 1476-4687
0028-0836
DOI: 10.48350/165217
Popis: X.D. was funded by a grant from the National Institute for Health Research (NIHR) Health Protection Research Unit in Genomics and Enabling Data (no. NIHR200892). M.A.H. was supported by grants from the Medical Research Council (nos. G1001787/1, MR/N002660/1 and MR/P007201/1) and the Economic and Social Research Council (no. ES/S000186/1). E.M.H. was supported by a UK Research and Innovation (UKRI) Fellowship (no. MR/S00291X/1). The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics1. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus—a notorious human pathogen—appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development. Publisher PDF
Databáze: OpenAIRE
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