Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts
| Autor: | Po Yee Chiu, Chung Wai Yan, Kam Ming Ko, Philip Y. Lam |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cytochrome
medicine.medical_treatment Drug Evaluation Preclinical Pharmacology medicine.disease_cause Lignans Cyclooctanes chemistry.chemical_compound Cytochrome P-450 Enzyme System Drug Discovery polycyclic compounds medicine Humans Polycyclic Compounds heterocyclic compounds Radiation Injuries Fibroblast Cells Cultured Schisandra Protease biology Plant Extracts organic chemicals General Medicine Metabolism Glutathione Fibroblasts carbohydrates (lipids) medicine.anatomical_structure nervous system Biochemistry chemistry Photoprotection Toxicity Sunlight biology.protein Matrix Metalloproteinase 1 Reactive Oxygen Species Oxidative stress Peptide Hydrolases Phytotherapy |
| Zdroj: | Fitoterapia. 82:682-691 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2011.02.010 |
| Popis: | The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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