Changes in Titin and Collagen Modulate Effects of Aerobic and Resistance Exercise on Diabetic Cardiac Function

Autor: Shunchang Li, Ismail Laher, Derun Gao, Quansheng Su, Min Liang
Rok vydání: 2018
Předmět:
0301 basic medicine
Cardiac function curve
Blood Glucose
Male
medicine.medical_specialty
Diabetic Cardiomyopathies
Fibrillar Collagens
Diastole
Pharmaceutical Science
030204 cardiovascular system & hematology
Ventricular Function
Left
Diabetes Mellitus
Experimental
Rats
Sprague-Dawley
03 medical and health sciences
Ventricular Dysfunction
Left
0302 clinical medicine
Internal medicine
Diabetes mellitus
Genetics
medicine
Aerobic exercise
Animals
Connectin
Myocytes
Cardiac
Genetics (clinical)
biology
Ventricular Remodeling
business.industry
Resistance training
Resistance Training
medicine.disease
Streptozotocin
Fibrosis
030104 developmental biology
Diabetes Mellitus
Type 2
biology.protein
Cardiology
Molecular Medicine
Titin
Insulin Resistance
Cardiology and Cardiovascular Medicine
Complication
business
medicine.drug
Zdroj: Journal of cardiovascular translational research. 12(5)
ISSN: 1937-5395
Popis: Diastolic dysfunction is a common complication that occurs early in diabetes mellitus. Titin and collagen are two important regulators of myocardial passive tension, which contributes to diabetic myocardial diastolic dysfunction. Exercise therapy significantly improves the impaired diabetic cardiac function, but its benefits appear to depend on the type of exercise used. We investigated the effect of aerobic and resistance exercise on cardiac diastolic function in diabetic rats induced by high-fat diet combined with low-dose streptozotocin injection. Interestingly, although resistance training had a more pronounced effect on blood glucose control than did aerobic training in type 2 diabetic rats, improvements in cardiac diastolic parameters benefited more from aerobic training. Moreover, aerobic exercise did significantly increase the expression levels of titin and decrease collagen I, TGFβ1 expression level. In summary, out data suggest that aerobic exercise may improve diabetic cardiac function through changes in titin-dependent myocardial stiffness rather than collagen-dependent interstitial fibrosis.
Databáze: OpenAIRE
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