Does povidone-iodine liposome hydrogel influence postoperative intraabdominal adhesions?
| Autor: | A. Gollu, M.A. Adibelli, A.H. Ozcan, K. Kismet, M.A. Akkus, Serap Erel, Bulent Kilicoglu |
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| Předmět: |
Male
medicine.medical_specialty Abrasion (medical) chemistry.chemical_element Adhesion (medicine) Tissue Adhesions Iodine Peritoneal Diseases Hydrogel Polyethylene Glycol Dimethacrylate Caecum Random Allocation Postoperative Complications Peritoneum Medicine Animals Rats Wistar Povidone-Iodine Liposome Tissue Adhesion Wound Healing biology business.industry General Medicine medicine.disease biology.organism_classification Surgery Rats Intestinal Diseases medicine.anatomical_structure chemistry Liposomes business Wound healing |
| Zdroj: | Publons |
| Popis: | To evaluate the effect of PVP-I liposome hydrogel on intraperitoneal postoperative adhesions.Thirty Wistar -Albino male rats were randomly divided into three groups. After midline laparotomy, a 1 cm(2) area of the caecum was abraded with a sterile gauze until subserosal haemorrhage had developed. A 1 x 1 cm patch of peritoneum located opposite of caecal abrasion was completely dissected. In group 1 (control group, C) adhesion induction was performed and nothing was applied to the wounds. In group 2 and 3, PVP-I solution (3%) (group 2, PI) and PVP-I liposome hydrogel (group 3, PIL) were applied to the caecal abrasion areas and peritoneal defects. Adhesions were classified according to a classification system based on the evaluation of the appearance, extent and strength of the adhesions on postoperative 2lst day.There was no significant difference of the adhesion scores between the groups (U1 = 45, p0.05 ; U2 = 48, p0.05 ; U3 = 47.5, p0.05).We found that PVP liposome hydrogel did not influence postoperative intraabdominal adhesions and should be further explored for its potential use in various intraabdominal procedures. |
| Databáze: | OpenAIRE |
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