Superoxide dismutase and the sigma1 receptor as key elements of the antioxidant system in human gastrointestinal tract cancers
| Autor: | Michał Skrzycki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
sigma1 receptor
Antioxidant General Immunology and Microbiology QH301-705.5 General Neuroscience medicine.medical_treatment gastrointestinal cancer Human gastrointestinal tract Biology Pharmacology superoxide dismutase General Biochemistry Genetics and Molecular Biology Superoxide dismutase medicine.anatomical_structure antioxidant enzymes biology.protein medicine oxidative stress Biology (General) General Agricultural and Biological Sciences Receptor Research Article |
| Zdroj: | Open Life Sciences, Vol 16, Iss 1, Pp 1225-1239 (2021) Open Life Sciences |
| ISSN: | 2391-5412 |
| Popis: | This long-term research was designed to evaluate whether superoxide dismutase (SOD) isoenzymes participate in the development of human gastrointestinal neoplasms and the potential influence of the sigma1 receptor (Sig1R) on the regulation of SOD gene expression during the neoplastic process. The experiments included human tissues from selected gastrointestinal tract tumors (liver cancer, colorectal adenocarcinoma, and colorectal cancer liver metastases). Activity, protein levels, and mRNA levels were determined for SOD isoenzymes and Sig1R. Additionally, markers of oxidative stress (glutathione, lipid peroxidation) were measured. The results showed significant changes in the antioxidant system activity in all examined types of tumors. SOD changed both in healthy cells and in neoplastic cells. The activity and expression of all studied enzymes significantly changed due to the advancement of tumor development. The Sig1R might be an additional regulator of the antioxidant system on which activity might depend on the survival and proliferation of cancer cells. Overall, the study shows that SOD1 and SOD2 are involved not only in the formation of neoplastic changes in the human gastrointestinal tissues (healthy intestine – colon tumor; healthy liver – liver cirrhosis – liver cancer) but also in the development of tumors in the sequence: benign tumor – malignant tumor – metastasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|