Possible contribution of IMRT in postoperative radiochemotherapy for rectal cancer: Analysis on 1798 patients by prediction model
| Autor: | Yueping Liu, Nicola Dinapoli, Yexiong Li, Yongwen Song, Xin Wang, Ningning Lu, E. Meldolesi, Hao Jing, Jing Jin, Weihu Wang, Qin Xiao, Hui Fang, Hua Ren, Wenyang Liu, Yanru Feng, Yu Tang, Lei Deng, Jian-yang Wang, Vincenzo Valentini, Shu-lian Wang, Maria Antonietta Gambacorta, Giuditta Chiloiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Intensity-modulated radiation therapy Survival Colorectal cancer medicine.medical_treatment Nomogram 03 medical and health sciences 0302 clinical medicine Internal medicine Adjuvant therapy Rectal Adenocarcinoma Medicine Humans 030212 general & internal medicine Rectal cancer Prospective cohort study Aged Proportional Hazards Models Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA Aged 80 and over Postoperative radiochemotherapy business.industry Proportional hazards model Rectal Neoplasms Rectum Cancer Chemoradiotherapy Middle Aged medicine.disease Combined Modality Therapy Surgery Radiation therapy Nomograms 030220 oncology & carcinogenesis Female Radiotherapy Intensity-Modulated business Research Paper |
| Zdroj: | Oncotarget |
| Popis: | // Wen-Yang Liu 1 , Nicola Dinapoli 2 , Xin Wang 1 , Elisa Meldolesi 2 , Maria Antonietta Gambacorta 2 , Giuditta Chiloiro 2 , Hua Ren 1 , Hui Fang 1 , Ning-Ning Lu 1 , Yu Tang 1 , Lei Deng 1 , Jian-Yang Wang 1 , Hao Jing 1 , Qin Xiao 1, 3 , Yan-Ru Feng 1 , Ye-Xiong Li 1 , Shu-Lian Wang 1 , Yong-Wen Song 1 , Yue-Ping Liu 1 , Wei-Hu Wang 1 , Vincenzo Valentini 2 , Jing Jin 1 1 Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 2 Department of Radiation Oncology, Universita Cattolica del Sacro Cuore, Rome, Italy 3 Department of Radiation Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, China Correspondence to: Nicola Dinapoli, email: nicola.dinapoli@policlinicogemelli.it Vincenzo Valentini, email: vvalentini@rm.unicatt.it Jing Jin, email: jingjin1025@163.com Keywords: rectal cancer, nomogram, survival, postoperative radiochemotherapy, intensity-modulated radiation therapy Received: November 06, 2015 Accepted: June 01, 2016 Published: June 22, 2016 ABSTRACT The evidence for adjuvant therapy in locally advanced rectal cancer after TME surgery is sparse. The aim of this study was to identify predicting factors of overall survival (OS) in these patients and combine them into a nomogram for individualized treatment. 1798 patients with pathologically staged II/III rectal adenocarcinoma treated by radical TME surgery from a single center’s database were reviewed. The nomogram was derived by Cox proportional hazards regression. Its performance was assessed by concordance index and calibration curve in internal validation with bootstrapping. Pooled Cox model analysis identified age, sex, grade of histology, pathological T and N stage, residual tumor, concurrent radiochemotherapy (RTCT), adjuvant chemotherapy cycles (CT), radiotherapy (RT) unexpected interruption days and intensity-modulated radiation therapy (IMRT) as significant covariates for 5-year OS (P |
| Databáze: | OpenAIRE |
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