White matter microstructure predicts longitudinal social cognitive outcomes after paediatric traumatic brain injury: a diffusion tensor imaging study
| Autor: | Nicholas P Ryan, Sila Genc, Simone J. Hearps, Vicki Anderson, Timothy J. Silk, Cathy Catroppa, K. O. Yeates, Miriam H. Beauchamp |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Adolescent Traumatic brain injury Theory of Mind Uncinate fasciculus Poison control Splenium Neuropsychological Tests Audiology Corpus callosum 050105 experimental psychology White matter 03 medical and health sciences Cognition 0302 clinical medicine Brain Injuries Traumatic medicine Humans 0501 psychology and cognitive sciences Longitudinal Studies Prospective Studies Child Social Behavior Psychiatry Applied Psychology 05 social sciences Australia medicine.disease White Matter Psychiatry and Mental health Diffusion Tensor Imaging medicine.anatomical_structure Multivariate Analysis Linear Models Female Psychology 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Psychological Medicine. 48:679-691 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundDeficits in social cognition may be among the most profound and disabling sequelae of paediatric traumatic brain injury (TBI); however, the neuroanatomical correlates of longitudinal outcomes in this domain remain unexplored. This study aimed to characterize social cognitive outcomes longitudinally after paediatric TBI, and to evaluate the use of sub-acute diffusion tensor imaging (DTI) to predict these outcomes.MethodsThe sample included 52 children with mild complex-severe TBI who were assessed on cognitive theory of mind (ToM), pragmatic language and affective ToM at 6- and 24-months post-injury. For comparison, 43 typically developing controls (TDCs) of similar age and sex were recruited. DTI data were acquired sub-acutely (mean = 5.5 weeks post-injury) in a subset of 65 children (TBI = 35; TDC = 30) to evaluate longitudinal prospective relationships between white matter microstructure assessed using Tract-Based Spatial Statistics and social cognitive outcomes.ResultsWhole brain voxel-wise analysis revealed significantly higher mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) in the sub-acute TBI group compared with TDC, with differences observed predominantly in the splenium of the corpus callosum (sCC), sagittal stratum (SS), dorsal cingulum (DC), uncinate fasciculus (UF) and middle and superior cerebellar peduncles (MCP & SCP, respectively). Relative to TDCs, children with TBI showed poorer cognitive ToM, affective ToM and pragmatic language at 6-months post-insult, and those deficits were related to abnormal diffusivity of the sCC, SS, DC, UF, MCP and SCP. Moreover, children with TBI showed poorer affective ToM and pragmatic language at 24-months post-injury, and those outcomes were predicted by sub-acute alterations in diffusivity of the DC and MCP.ConclusionsAbnormal microstructure within frontal-temporal, limbic and cerebro-cerebellar white matter may be a risk factor for long-term social difficulties observed in children with TBI. DTI may have potential to unlock early prognostic markers of long-term social outcomes. |
| Databáze: | OpenAIRE |
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