Default mode network connectivity and social dysfunction in major depressive disorder
| Autor: | Nic J.A. van der Wee, Dick J. Veltman, Moji Aghajani, Ilja M.J. Saris, Marie-José van Tol, Richard Dinga, Brenda W.J.H. Penninx |
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| Přispěvatelé: | Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Anatomy and neurosciences, APH - Digital Health, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
lcsh:Medicine ACTIVATION 0302 clinical medicine Neural Pathways SCHIZOPHRENIA SUPPORT Longitudinal Studies lcsh:Science Prefrontal cortex Default mode network Netherlands Multidisciplinary Depression Brain Loneliness Cognition DIMENSIONAL APPROACH Schizophrenia Social behaviour Major depressive disorder Female HEALTH medicine.symptom Psychology Adult CORTEX behavioral disciplines and activities Article 03 medical and health sciences Human behaviour medicine Humans Depressive Disorder Major Social network business.industry Functional Neuroimaging STATE FUNCTIONAL CONNECTIVITY 1ST-EPISODE DISABILITY lcsh:R Social Behavior Disorders medicine.disease 030227 psychiatry Superior frontal gyrus COGNITION lcsh:Q business Neuroscience human activities 030217 neurology & neurosurgery |
| Zdroj: | Saris, I M J, Penninx, B W J H, Dinga, R, van Tol, M J, Veltman, D J, van der Wee, N J A & Aghajani, M 2020, ' Default Mode Network Connectivity and Social Dysfunction in Major Depressive Disorder ', Scientific Reports, vol. 10, no. 1, 194 . https://doi.org/10.1038/s41598-019-57033-2 Scientific Reports, 10, 194 Scientific Reports, 10(1):194. Nature Publishing Group Scientific Reports, 10(1). NATURE PUBLISHING GROUP Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Though social functioning is often hampered in Major Depressive Disorder (MDD), we lack a complete and integrated understanding of the underlying neurobiology. Connectional disturbances in the brain’s Default Mode Network (DMN) might be an associated factor, as they could relate to suboptimal social processing. DMN connectional integrity, however, has not been explicitly studied in relation to social dysfunctioning in MDD patients. Applying Independent Component Analysis and Dual Regression on resting-state fMRI data, we explored DMN intrinsic functional connectivity in relation to social dysfunctioning (i.e. composite of loneliness, social disability, small social network) among 74 MDD patients (66.2% female, Mean age = 36.9, SD = 11.9). Categorical analyses examined whether DMN connectivity differs between high and low social dysfunctioning MDD groups, dimensional analyses studied linear associations between social dysfunction and DMN connectivity across MDD patients. Threshold-free cluster enhancement (TFCE) with family-wise error (FWE) correction was used for statistical thresholding and multiple comparisons correction (P |
| Databáze: | OpenAIRE |
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