Clonal Chromosome Abnormalities in Enchondromas and Chondrosarcomas
| Autor: | Bastian Gunawan, Joachim E. Wildberger, Marc Weber, Frank Bergmann, László Füzesi, F.U Niethard |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male musculoskeletal diseases Cancer Research medicine.medical_specialty Pathology Adolescent Chondrosarcoma Chromosome Disorders Biology Translocation Genetic Tumor Cells Cultured Genetics Enchondroma medicine Humans Molecular Biology Aged Chromosome Aberrations Cytogenetics Chromosome Karyotype Middle Aged musculoskeletal system medicine.disease Chromosome Banding Clone Cells Karyotyping Grade II Chondrosarcoma Female Clone (B-cell biology) Chondroma |
| Zdroj: | Cancer Genetics and Cytogenetics. 120:127-130 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(99)00254-x |
| Popis: | We report cytogenetic findings in short-term cell cultures from five enchondromas and four chondrosarcomas. Clonal chromosome aberrations were found in one case of enchondroma, and in all cases of chondrosarcoma. The only enchondroma with nonrandom abnormalities had a reciprocal t(8;17)(q23;p13), and monosomies 9, 19, and/or 22. In contrast to the few karyotypic findings in one of five enchondromas, the four chondrosarcomas were commonly characterized by cytogenetic heterogeneity, with a tendency for increasing karyotypic complexity in higher grade tumors. Two cases, one grade III and one metastasizing grade II chondrosarcoma, revealed hypodiploid stem- and sidelines with loss of chromosomes 6, 10, 13, 14, and 22, as common chromosomal abnormalities, suggesting a distinct karyotypic pattern in a subset of biologically aggressive chondrosarcomas. |
| Databáze: | OpenAIRE |
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