Nitrocinnamate-Functionalized Gelatin: Synthesis and 'Smart' Hydrogel Formation via Photo-Cross-Linking
| Autor: | Kerim M. Gattás-Asfura, Bill Muller, Roger M. Leblanc, Eric Weisman, Miodrag Micic, Fotios M. Andreopoulos, Si M. Pham, Sanjeev Sirpal |
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| Rok vydání: | 2005 |
| Předmět: |
food.ingredient
Polymers and Plastics Ultraviolet Rays Nitro compound Bioengineering Gelatin Micelle Catalysis Biomaterials food Polymer chemistry Materials Chemistry medicine chemistry.chemical_classification Aqueous solution Chemistry technology industry and agriculture Chemical modification Hydrogels Cross-Linking Reagents Cinnamates Ionic strength Swelling medicine.symptom Photic Stimulation Nuclear chemistry |
| Zdroj: | Biomacromolecules. 6:1503-1509 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/bm049238w |
| Popis: | Gelatin having p-nitrocinnamate pendant groups (Gel-NC) was prepared via an efficient one-pot synthesis, yield87%. (1)H NMR data indicated that 1 mol of gelatin was modified with 18 +/- 6 mol of the photosensitive group. Upon exposure to low-intensity 365 nm UV light and in the absence of photoinitiators or catalysts, Gel-NC cross-linked within minutes into a gelatin-based hydrogel as monitored by UV-vis spectroscopy. The degree of swelling of this biodegradable hydrogel in aqueous solutions responded to changes in Gel-NC concentration levels, the ionic strength of the aqueous solutions, and photo-cross-linking time. Topography changes associated with phase transition resulting from "photocleavage" of the hydrogel network with 254 nm UV light were studied with AFM. Both Gel-NC and its hydrogel expressed low toxicity to human neonatal fibroblast cells. In addition, gelatin-based microgels were prepared via the photo-cross-linking of Gel-NC within inverse micelles. |
| Databáze: | OpenAIRE |
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