Detecting the vulnerable carotid plaque: The Carotid Artery Multimodality imaging Prognostic study design
| Autor: | Luna Gargani, Matteo Baldini, Raffaella Berchiolli, Ida Rebecca Bort, Giancarlo Casolo, Dante Chiappino, Mirco Cosottini, Gennaro D’Angelo, Mariella De Santis, Paola Erba, Iacopo Fabiani, Plinio Fabiani, Ilaria Gabbriellini, Gian Giacomo Galeotti, Irene Ghicopulos, Isabel Goncalves, Simone Lapi, Gabriele Masini, Carmela Morizzo, Vinicio Napoli, Jan Nilsson, Giovanni Orlandi, Carlo Palombo, Francesco Pieraccini, Stefano Ricci, Gabriele Siciliano, Riemer H.J.A. Slart, Raffaele De Caterina |
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| Přispěvatelé: | Gargani, L, Baldini, M, Berchiolli, R, Bort, I, Casolo, G, Chiappino, D, Cosottini, M, D'Angelo, G, De Santis, M, Erba, P, Fabiani, I, Fabiani, P, Gabbriellini, I, Galeotti, G, Ghicopulos, I, Goncalves, I, Lapi, S, Masini, G, Morizzo, C, Napoli, V, Nilsson, J, Orlandi, G, Palombo, C, Pieraccini, F, Ricci, S, Siciliano, G, Slart, R, De Caterina, R, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Translational Immunology Groningen (TRIGR), Cardiovascular Centre (CVC) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Carotid Artery Diseases
Dementia Vascular carotid ultrasound vascular dementia General Medicine carotid artery disease Prognosis Multimodal Imaging stroke Plaque Atherosclerotic Carotid Arteries atherosclerosi vascular imaging Humans magnetic resonance imaging Prospective Studies carotid artery plaque atherosclerosis Cardiology and Cardiovascular Medicine Ischemic Stroke |
| Zdroj: | Journal of cardiovascular medicine (Hagerstown, Md.), 23(7), 466-473 |
| ISSN: | 1558-2035 |
| Popis: | BACKGROUND: Carotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic resonance imaging, positron emission tomography, and computed tomography.OBJECTIVES: The Carotid Artery Multimodality imaging Prognostic (CAMP) study will: prospectively determine the best predictors of silent and overt ischemic stroke and vascular dementia in patients with asymptomatic subcritical carotid artery disease by identifying the noninvasive diagnostic features of the 'vulnerable carotid plaque'; assess whether 'smart' use of low-cost diagnostic methods such as ultrasound-based evaluations may yield at least the same level of prospective information as more expensive techniques.STUDY DESIGN: We will compare the prognostic/predictive value of all proposed techniques with regard to silent or clinically manifest ischemic stroke and vascular dementia. The study will include ≥300 patients with asymptomatic, unilateral, intermediate degree (40-60% diameter) common or internal carotid artery stenosis detected at carotid ultrasound, with a 2-year follow-up. The study design has been registered on Clinicaltrial.gov on December 17, 2020 (ID number NCT04679727). |
| Databáze: | OpenAIRE |
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