Association between serum angiopoietin-2 concentrations and periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention
| Autor: | Chun Gui, Wen Jian, Zhi-Jie Yang, Guo-Liang Yang, Yu-Tao Xu, Qi-Li Huang, Chun-Mei Wei, Can Wang, Chang-Hua Mo, Wen-Bo Zheng, Jia-Hui Guan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Aging medicine.medical_specialty medicine.drug_class medicine.medical_treatment Coronary artery disease Angiopoietin-2 Risk Factors Internal medicine medicine Natriuretic peptide Humans In patient Perioperative Period Aged biology business.industry Angiopoietin 2 Myocardium percutaneous coronary intervention Stent Percutaneous coronary intervention Cell Biology Middle Aged medicine.disease Troponin Heart Injuries NT-proBNP Conventional PCI biology.protein Cardiology Female business hormones hormone substitutes and hormone antagonists perioperative myocardial injury coronary artery disease Biomarkers Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Angiopoietin-2 (Ang-2) is a proangiogenic factor that mediates inflammation and atherosclerosis. We evaluated the predictive value of circulating Ang-2 levels for periprocedural myocardial injury (PMI) in 145 patients undergoing elective percutaneous coronary intervention (PCI), and investigated whether post-PCI Ang-2 levels are influenced by PMI. PMI was defined as a post-procedural troponin elevation above the 5×99th percentile upper reference limit. Blood samples for Ang-2 analysis were collected at admission and on postoperative days 1 and 3. PMI occurred in 40 patients (28%). At baseline, there was no difference in Ang-2 levels between PMI and non-PMI patients (P=0.554). However, a significant interaction effect between PMI occurrence and time on Ang-2 levels was observed (interaction P=0.036). Although serum Ang-2 levels in non-PMI patients gradually decreased, Ang-2 levels in PMI patients did not change between different time-points. Multiple logistic regression analysis revealed that age, total stent length, and serum levels of N-terminal pro-brain natriuretic peptide were independent PMI predictors. These findings indicate that pre-procedural Ang-2 levels do not impact PMI occurrence after elective PCI. However, changes in Ang-2 levels after the procedure are closely related to PMI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|