Stitching Oxindoles and Ynones in a Domino Process: Access to Spirooxindoles and Application to a Short Synthesis of Spindomycin B

Autor:	Goverdhan Mehta, Jaipal Madapa, Ramesh Samineni, Srihari Pabbaraja
Rok vydání:	2017
Předmět:	010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Substitution (logic) 010402 general chemistry 01 natural sciences Biochemistry Domino 0104 chemical sciences Image stitching Spindomycin B Domino process Physical and Theoretical Chemistry
Zdroj:	Organic letters. 19(22)
ISSN:	1523-7052
Popis:	A general, transition-metal-free, one-pot, domino Michael–SNAr or AdNE substitution protocol was devised for spiroannulation of oxindoles with ortho-bromoaryl ynones, β-bromoalkenyl ynones, and β-bromoalkenyl enones in a convenient and efficient manner. As an application, a short synthesis of tetracyclic alkaloid spindomycin B was accomplished.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b7468c6e49d6b77e939a460dc38efa https://pubmed.ncbi.nlm.nih.gov/29148813 Zobrazit plný text záznamu