Pharmacology, mechanisms of action and uses of selective phosphodiesterase inhibitors
| Autor: | K.M. Sherry, J.R. Skoyles |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Inotrope
Sympathetic nervous system Cardiac output business.industry Phosphodiesterase Inhibitors Vasodilator Agents Management of heart failure Cardiac Output Low Hemodynamics Phosphodiesterase Vasodilation Pharmacology medicine.disease Myocardial Contraction Anesthesiology and Pain Medicine medicine.anatomical_structure Heart failure medicine Vascular resistance Humans business |
| Zdroj: | British journal of anaesthesia. 68(3) |
| ISSN: | 0007-0912 |
| Popis: | Anaesthetists are often involved in the treatment of heart failure in both the intensive care unit and during cardiac anaesthesia. Regardless of its aetiology, heart failure is associated with a reduction in cardiac output, increase in filling pressures and dilatation or hypertrophy of the myocardium. Secondary to this is stimulation of the renin-angiotensin axis, sympathetic nervous system and atrial naturetic peptides, leading to increased systemic vascular resistance and fluid retention. The management of heart failure is directed to the treatment of die underlying cause and manipulation of the circulation by diuretics, vasodilators and drugs with inotropic activity. This article reviews the selective phosphodiesterase inhibitors which have both inotropic and vasodilator activity. HISTORICAL PERSPECTIVE |
| Databáze: | OpenAIRE |
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