3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling
| Autor: | Suresh Bandari, Arun Butreddy, Nagireddy Dumpa, Neeraja Komanduri, Michael A. Repka, Honghe Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Computer science
Pharmaceutical Science 3D printing 02 engineering and technology Raw material 030226 pharmacology & pharmacy Article law.invention Personalization 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine law Humans Technology Pharmaceutical Process engineering Fused deposition modeling Inkwell business.industry Hot Melt Extrusion Technology 021001 nanoscience & nanotechnology Pharmaceutical Preparations Printing Three-Dimensional Drug delivery Pharmaceutical manufacturing Extrusion 0210 nano-technology business |
| Zdroj: | Int J Pharm |
| ISSN: | 0378-5173 |
| Popis: | Advancements in pharmaceutical technologies have led to the personalization of therapies over the last decade. Three-dimensional printing (3DP) is an emerging technique in the manufacturing of pharmaceutical dosage forms because of its potential to create complex and customized dosage forms according to the patient’s needs. Among the various 3DP techniques based on different functioning mechanisms, fused deposition modeling (FDM) 3D printing is a versatile and widely used method with advantages such as precision of quantity and the ability to incorporate different fill densities. This method is also economical and easily produces complex designs. Hot-melt extrusion (HME) is an established technique in pharmaceutical manufacturing that is utilized in the development of filaments which are used as “ink roll” or feedstock material in FDM 3D printing. This review discusses the various stages involved in FDM 3D printing, including feedstock filament preparation using HME, digital dosage form designs, filament characterization, and various novel applications, and future perspectives. |
| Databáze: | OpenAIRE |
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